Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation

Ramin Bighamian; Bahram Parvinian; Christopher G. Scully; George Kramer; Jin Oh Hahn

doi:10.1016/j.conengprac.2018.01.008

Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation

Ramin Bighamian, Bahram Parvinian, Christopher G. Scully, George Kramer, Jin Oh Hahn

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

This paper presents a physiological model to reproduce hemodynamic responses to blood volume perturbation. The model consists of three sub-models: a control-theoretic model relating blood volume response to blood volume perturbation; a simple physics-based model relating blood volume to stroke volume and cardiac output; and a phenomenological model relating cardiac output to blood pressure. A unique characteristic of this model is its balance for simplicity and physiological transparency. Initial validity of the model was examined using experimental data collected from 11 animals. The model may serve as a viable basis for the design and evaluation of closed-loop fluid resuscitation controllers.

Original language	English (US)
Pages (from-to)	149-160
Number of pages	12
Journal	Control Engineering Practice
Volume	73
DOIs	https://doi.org/10.1016/j.conengprac.2018.01.008
State	Published - Apr 2018
Externally published	Yes

Keywords

Blood volume
Fluid infusion
Fluid resuscitation
Hemodynamic response
Hemorrhage
Mathematical model
Physiological closed-loop control

ASJC Scopus subject areas

Control and Systems Engineering
Computer Science Applications
Electrical and Electronic Engineering
Applied Mathematics

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10.1016/j.conengprac.2018.01.008

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title = "Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation",

abstract = "This paper presents a physiological model to reproduce hemodynamic responses to blood volume perturbation. The model consists of three sub-models: a control-theoretic model relating blood volume response to blood volume perturbation; a simple physics-based model relating blood volume to stroke volume and cardiac output; and a phenomenological model relating cardiac output to blood pressure. A unique characteristic of this model is its balance for simplicity and physiological transparency. Initial validity of the model was examined using experimental data collected from 11 animals. The model may serve as a viable basis for the design and evaluation of closed-loop fluid resuscitation controllers.",

keywords = "Blood volume, Fluid infusion, Fluid resuscitation, Hemodynamic response, Hemorrhage, Mathematical model, Physiological closed-loop control",

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doi = "10.1016/j.conengprac.2018.01.008",

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T1 - Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation

AU - Bighamian, Ramin

AU - Parvinian, Bahram

AU - Scully, Christopher G.

AU - Kramer, George

AU - Hahn, Jin Oh

PY - 2018/4

Y1 - 2018/4

N2 - This paper presents a physiological model to reproduce hemodynamic responses to blood volume perturbation. The model consists of three sub-models: a control-theoretic model relating blood volume response to blood volume perturbation; a simple physics-based model relating blood volume to stroke volume and cardiac output; and a phenomenological model relating cardiac output to blood pressure. A unique characteristic of this model is its balance for simplicity and physiological transparency. Initial validity of the model was examined using experimental data collected from 11 animals. The model may serve as a viable basis for the design and evaluation of closed-loop fluid resuscitation controllers.

AB - This paper presents a physiological model to reproduce hemodynamic responses to blood volume perturbation. The model consists of three sub-models: a control-theoretic model relating blood volume response to blood volume perturbation; a simple physics-based model relating blood volume to stroke volume and cardiac output; and a phenomenological model relating cardiac output to blood pressure. A unique characteristic of this model is its balance for simplicity and physiological transparency. Initial validity of the model was examined using experimental data collected from 11 animals. The model may serve as a viable basis for the design and evaluation of closed-loop fluid resuscitation controllers.

KW - Blood volume

KW - Fluid infusion

KW - Fluid resuscitation

KW - Hemodynamic response

KW - Hemorrhage

KW - Mathematical model

KW - Physiological closed-loop control

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JO - Control Engineering Practice

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Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation

Abstract

Keywords

ASJC Scopus subject areas

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