Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation

Ramin Bighamian, Bahram Parvinian, Christopher G. Scully, George Kramer, Jin Oh Hahn

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This paper presents a physiological model to reproduce hemodynamic responses to blood volume perturbation. The model consists of three sub-models: a control-theoretic model relating blood volume response to blood volume perturbation; a simple physics-based model relating blood volume to stroke volume and cardiac output; and a phenomenological model relating cardiac output to blood pressure. A unique characteristic of this model is its balance for simplicity and physiological transparency. Initial validity of the model was examined using experimental data collected from 11 animals. The model may serve as a viable basis for the design and evaluation of closed-loop fluid resuscitation controllers.

Original languageEnglish (US)
Pages (from-to)149-160
Number of pages12
JournalControl Engineering Practice
Volume73
DOIs
StatePublished - Apr 1 2018

Fingerprint

Hemodynamics
Blood
Perturbation
Modeling
Cardiac Output
Model
Physiological models
Physiological Model
Resuscitation
Blood pressure
Blood Pressure
Transparency
Stroke
Closed-loop
Animals
Simplicity
Physics
Experimental Data
Controller
Fluid

Keywords

  • Blood volume
  • Fluid infusion
  • Fluid resuscitation
  • Hemodynamic response
  • Hemorrhage
  • Mathematical model
  • Physiological closed-loop control

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Applied Mathematics

Cite this

Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation. / Bighamian, Ramin; Parvinian, Bahram; Scully, Christopher G.; Kramer, George; Hahn, Jin Oh.

In: Control Engineering Practice, Vol. 73, 01.04.2018, p. 149-160.

Research output: Contribution to journalArticle

Bighamian, Ramin ; Parvinian, Bahram ; Scully, Christopher G. ; Kramer, George ; Hahn, Jin Oh. / Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation. In: Control Engineering Practice. 2018 ; Vol. 73. pp. 149-160.
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