Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation

Ramin Bighamian, Bahram Parvinian, Christopher G. Scully, George Kramer, Jin Oh Hahn

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


This paper presents a physiological model to reproduce hemodynamic responses to blood volume perturbation. The model consists of three sub-models: a control-theoretic model relating blood volume response to blood volume perturbation; a simple physics-based model relating blood volume to stroke volume and cardiac output; and a phenomenological model relating cardiac output to blood pressure. A unique characteristic of this model is its balance for simplicity and physiological transparency. Initial validity of the model was examined using experimental data collected from 11 animals. The model may serve as a viable basis for the design and evaluation of closed-loop fluid resuscitation controllers.

Original languageEnglish (US)
Pages (from-to)149-160
Number of pages12
JournalControl Engineering Practice
StatePublished - Apr 2018


  • Blood volume
  • Fluid infusion
  • Fluid resuscitation
  • Hemodynamic response
  • Hemorrhage
  • Mathematical model
  • Physiological closed-loop control

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Applied Mathematics


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