Controlled clinical study of skin donor sites and deep partial-thickness burns treated with cultured epidermal allografts

Maria Rivas-Torres, Dante Amato, Héctor Arámbula-Alvarez, Walid Kuri-Harcuch

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Two clinical studies in donor site and deep partial-thickness burns treated with banked cultured human epidermal allografts are described. Ten burn patients were subjected to donor split-thickness skin harvesting. The study was controlled, side-by-side comparative, blind, and randomized. Banked cultured epidermal allografts promote a faster reepithelialization of the wounds; they epithelialized in an average of 6.9 days, whereas controls healed in an average of 11.1 days, giving a reduction of 37.8 percent in time to heal (p < 0.005). Allografted sites were less erythematous as compared with controls (p < 0.01), with more tendency to normopigmentation. In the deep partial-thickness burns study, 10 patients with 18 burned wounds were treated. Wounds treated with cultured allografts showed complete reepithelialization in about 3 to 6 days. The two clinical studies showed that banked cultured epidermal allograft promotes a significantly faster epithelialization of donor sites and deep partial-thickness wounds. These results support the idea that cultured allografts should be used routinely to improve treatment of burn patients and reduce their therapy time.

Original languageEnglish (US)
Pages (from-to)279-287
Number of pages9
JournalPlastic and Reconstructive Surgery
Volume98
Issue number2
DOIs
StatePublished - Aug 1996
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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