Nanopatterned arrays of biomolecules are a powerful tool to address fundamental issues in many areas of biology. DNA nanoarrays, in particular, are of interest in the study of DNA-protein interactions and for biodiagnostic investigations. In this context, achieving a highly specific nanoscale assembly of oligonucleotides at surfaces is critical. In this chapter, we describe a method to control the immobilization of DNA on nanopatterned surfaces; the nanofabrication and the bio-functionalization involved in the process will be discussed.
|Original language||English (US)|
|Number of pages||17|
|Journal||Methods in molecular biology (Clifton, N.J.)|
|State||Published - Jan 1 2011|
ASJC Scopus subject areas
- Molecular Biology