Controlled confinement of DNA at the nanoscale: nanofabrication and surface bio-functionalization.

Matteo Palma, Justin J. Abramson, Alon A. Gorodetsky, Colin Nuckolls, Michael Sheetz, Shalom J. Wind, James Hone

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Nanopatterned arrays of biomolecules are a powerful tool to address fundamental issues in many areas of biology. DNA nanoarrays, in particular, are of interest in the study of DNA-protein interactions and for biodiagnostic investigations. In this context, achieving a highly specific nanoscale assembly of oligonucleotides at surfaces is critical. In this chapter, we describe a method to control the immobilization of DNA on nanopatterned surfaces; the nanofabrication and the bio-functionalization involved in the process will be discussed.

Original languageEnglish (US)
Pages (from-to)169-185
Number of pages17
JournalMethods in molecular biology (Clifton, N.J.)
Volume749
StatePublished - Jan 1 2011
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Palma, M., Abramson, J. J., Gorodetsky, A. A., Nuckolls, C., Sheetz, M., Wind, S. J., & Hone, J. (2011). Controlled confinement of DNA at the nanoscale: nanofabrication and surface bio-functionalization. Methods in molecular biology (Clifton, N.J.), 749, 169-185.