Controlled Confinement of DNA at the Nanoscale: Nanofabrication and Surface Bio-Functionalization

Matteo Palma, Justin J. Abramson, Alon A. Gorodetsky, Colin Nuckolls, Michael P. Sheetz, Shalom J. Wind, James Hone

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations


Nanopatterned arrays of biomolecules are a powerful tool to address fundamental issues in many areas of biology. DNA nanoarrays, in particular, are of interest in the study of DNA–protein interactions and for biodiagnostic investigations. In this context, achieving a highly specific nanoscale assembly of oligonucleotides at surfaces is critical. In this chapter, we describe a method to control the immobilization of DNA on nanopatterned surfaces; the nanofabrication and the bio-functionalization involved in the process will be discussed.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages17
StatePublished - 2011
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


  • DNA
  • Fluorescence microscopy
  • Nanoscale
  • Nanotechnology
  • Self-assembly

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


Dive into the research topics of 'Controlled Confinement of DNA at the Nanoscale: Nanofabrication and Surface Bio-Functionalization'. Together they form a unique fingerprint.

Cite this