Controlled photo stimulation of neuron cells and activation of calcium ions on semiconductor quantum dot layer-by-layer assemblies

Wasala M S Wickramanayake, Nicholas A. Kotov, Todd C. Poppas, Massoud Motamedi, Malcolm Broadwick, Burgess N. Christensen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The controlled activation of electrically excitable cells via a biocompatible interface is of considerable interest for treatments of neuronal injuries and sensory deficits. Quantum dot layer-by-layer (LBL) assemblies show specific current and voltage responses for different layer sequences which can be exploited for controlled neuron stimulation. Neuron cells were successfully grown on surface modified LBL assemblies and the flexible biocompatible surfaces of LBL assemblies facilitate the growth of dendrites of neurons closer to the interface resulting low activation barrier for stimulation. We report the layer sequence characteristic photo stimulation properties and calcium ion activation of neuron cells. Both biocompatibility and optical-electrical-bio coupling processes at the interface are improved by introducing different sequences of layers of LBL materials. For this investigation, NG108-115 neuron cells were grown on PDDA/HgTe LBL assemblies and both electrochemical and conforcal microscopic techniques were used.

Original languageEnglish (US)
Title of host publicationAIChE Annual Meeting, Conference Proceedings
Pages14127
Number of pages1
StatePublished - 2005
Externally publishedYes
Event05AIChE: 2005 AIChE Annual Meeting and Fall Showcase - Cincinnati, OH, United States
Duration: Oct 30 2005Nov 4 2005

Other

Other05AIChE: 2005 AIChE Annual Meeting and Fall Showcase
CountryUnited States
CityCincinnati, OH
Period10/30/0511/4/05

Fingerprint

Semiconductor quantum dots
Neurons
Calcium
Chemical activation
Ions
Biocompatibility
Electric potential

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Wickramanayake, W. M. S., Kotov, N. A., Poppas, T. C., Motamedi, M., Broadwick, M., & Christensen, B. N. (2005). Controlled photo stimulation of neuron cells and activation of calcium ions on semiconductor quantum dot layer-by-layer assemblies. In AIChE Annual Meeting, Conference Proceedings (pp. 14127)

Controlled photo stimulation of neuron cells and activation of calcium ions on semiconductor quantum dot layer-by-layer assemblies. / Wickramanayake, Wasala M S; Kotov, Nicholas A.; Poppas, Todd C.; Motamedi, Massoud; Broadwick, Malcolm; Christensen, Burgess N.

AIChE Annual Meeting, Conference Proceedings. 2005. p. 14127.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wickramanayake, WMS, Kotov, NA, Poppas, TC, Motamedi, M, Broadwick, M & Christensen, BN 2005, Controlled photo stimulation of neuron cells and activation of calcium ions on semiconductor quantum dot layer-by-layer assemblies. in AIChE Annual Meeting, Conference Proceedings. pp. 14127, 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Cincinnati, OH, United States, 10/30/05.
Wickramanayake WMS, Kotov NA, Poppas TC, Motamedi M, Broadwick M, Christensen BN. Controlled photo stimulation of neuron cells and activation of calcium ions on semiconductor quantum dot layer-by-layer assemblies. In AIChE Annual Meeting, Conference Proceedings. 2005. p. 14127
Wickramanayake, Wasala M S ; Kotov, Nicholas A. ; Poppas, Todd C. ; Motamedi, Massoud ; Broadwick, Malcolm ; Christensen, Burgess N. / Controlled photo stimulation of neuron cells and activation of calcium ions on semiconductor quantum dot layer-by-layer assemblies. AIChE Annual Meeting, Conference Proceedings. 2005. pp. 14127
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