Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats

Noelle Anastasio, Sonja J. Stutz, Amanda E. Price, Brionna D. Davis-Reyes, Dennis J. Sholler, Susan M. Ferguson, John F. Neumaier, F. Gerard Moeller, Jonathan Hommel, Kathryn Cunningham

Research output: Contribution to journalArticle

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Abstract

Food intake is essential for survival, but maladaptive patterns of intake, possibly encoded by a preexisting vulnerability coupled with the influence of environmental variables, can modify the reward value of food. Impulsivity, a predisposition toward rapid unplanned reactions to stimuli, is one of the multifaceted determinants underlying the etiology of dysregulated eating and its evolving pathogenesis. The medial prefrontal cortex (mPFC) is a major neural director of reward-driven behavior and impulsivity. Compromised signaling between the mPFC and nucleus accumbens shell (NAcSh) is thought to underlie the cognitive inability to withhold prepotent responses (motor impulsivity) and binge intake of high-fat food (HFF) seen in binge eating disorder. To explore the relationship between motor impulsivity and binge-like eating in rodents, we identified high (HI) and low impulsive (LI) rats in the 1-choice serial reaction time task and employed a rat model of binge-like eating behavior. HFF binge rats consumed significantly greater calories relative to control rats maintained on continual access to standard food or HFF. HI rats repeatedly exhibited significantly higher bingeing on HFF vs. LI rats. Next, we employed dual viral vector chemogenetic technology which allows for the targeted and isolated modulation of ventral mPFC (vmPFC) neurons that project to the NAcSh. Chemogenetic activation of the vmPFC to NAcSh pathway significantly suppressed motor impulsivity and binge-like intake for high-fat food. Thus, inherent motor impulsivity and binge-like eating are linked and the vmPFC to NAcSh pathway serves as a ‘brake’ over both behaviors.

Original languageEnglish (US)
JournalNeuropsychopharmacology
DOIs
StatePublished - Jan 1 2019

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Bulimia
Impulsive Behavior
Sprague Dawley Rats
Fats
Food
Nucleus Accumbens
Prefrontal Cortex
Reward
Eating
Binge-Eating Disorder
Feeding Behavior
Reaction Time
Rodentia
Technology
Neurons

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats. / Anastasio, Noelle; Stutz, Sonja J.; Price, Amanda E.; Davis-Reyes, Brionna D.; Sholler, Dennis J.; Ferguson, Susan M.; Neumaier, John F.; Moeller, F. Gerard; Hommel, Jonathan; Cunningham, Kathryn.

In: Neuropsychopharmacology, 01.01.2019.

Research output: Contribution to journalArticle

Anastasio, Noelle ; Stutz, Sonja J. ; Price, Amanda E. ; Davis-Reyes, Brionna D. ; Sholler, Dennis J. ; Ferguson, Susan M. ; Neumaier, John F. ; Moeller, F. Gerard ; Hommel, Jonathan ; Cunningham, Kathryn. / Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats. In: Neuropsychopharmacology. 2019.
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