Corazonin in insects

Reinhard Predel, Susanne Neupert, William Russell, Olaf Scheibner, Ronald J. Nachman

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Corazonin is a peptidergic neurohormone of insects that is expressed in neurosecretory neurons of the pars lateralis of the protocerebrum and transported via nervi corporis cardiaci to the storage lobes of the corpora cardiaca. This peptide occurs with a single isoform in all insects studied so far, with the exception of the Coleoptera in which no corazonin form could be detected. Very few modifications of [Arg7]-corazonin, originally isolated from cockroaches, are known, namely [His7]-corazonin which is expressed in certain locusts and the stick insect Carausius morosus, and [Thr4, His7]-corazonin recently described from the honey bee Apis mellifera. In this study, we performed a comprehensive screening for corazonin in the different insect groups after detecting of a fourth isoform in a crane fly, Tipula sp. ([Gln10]-corazonin). [Arg7]-corazonin is distributed in most major lineages of insects, and is thus the ancient form which was present at the time the phylum Insecta evolved. The replacement of Arg with His at position 7 from the N-terminus occurred several times in the evolution of insects. The third isoform, [Thr4, His7]-corazonin, seems to be restricted to bees (Apidae); whereas wasps (Vespidae) and a bumble bee (Apidae) express other corazonins, specifically [His7]-corazonin and [Tyr3, Gln7, Gln10]-corazonin, respectively. A novel corazonin form, [His4, Gln7]-corazonin, was also detected in all South African members of the newly described insect order Mantophasmatodea. The [His4, Gln7]-corazonin separates these species from the Namibian Mantophasmatodea which express [Arg7]-corazonin and can be used as a distinct character to distinguish these morphologically similar insects.

Original languageEnglish (US)
Pages (from-to)3-10
Number of pages8
JournalPeptides
Volume28
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

Fingerprint

Insects
Bees
Protein Isoforms
insect corazonin protein
Corpora Allata
Wasps
Cockroaches
Grasshoppers
Honey
Beetles
Cranes
Diptera
Neurons
Neurotransmitter Agents
Screening

Keywords

  • Diptera
  • Hymenoptera
  • Insect neuropeptide
  • Mantophasmatodea
  • Mass spectrometry

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Predel, R., Neupert, S., Russell, W., Scheibner, O., & Nachman, R. J. (2007). Corazonin in insects. Peptides, 28(1), 3-10. https://doi.org/10.1016/j.peptides.2006.10.011

Corazonin in insects. / Predel, Reinhard; Neupert, Susanne; Russell, William; Scheibner, Olaf; Nachman, Ronald J.

In: Peptides, Vol. 28, No. 1, 01.2007, p. 3-10.

Research output: Contribution to journalArticle

Predel, R, Neupert, S, Russell, W, Scheibner, O & Nachman, RJ 2007, 'Corazonin in insects', Peptides, vol. 28, no. 1, pp. 3-10. https://doi.org/10.1016/j.peptides.2006.10.011
Predel R, Neupert S, Russell W, Scheibner O, Nachman RJ. Corazonin in insects. Peptides. 2007 Jan;28(1):3-10. https://doi.org/10.1016/j.peptides.2006.10.011
Predel, Reinhard ; Neupert, Susanne ; Russell, William ; Scheibner, Olaf ; Nachman, Ronald J. / Corazonin in insects. In: Peptides. 2007 ; Vol. 28, No. 1. pp. 3-10.
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