TY - JOUR
T1 - Coronary Microvascular Disease
AU - Thakker, Ravi A.
AU - Rodriguez Lozano, Jorge
AU - Rodriguez Lozano, Patricia
AU - Motiwala, Afaq
AU - Rangasetty, Umamahesh
AU - Khalife, Wissam
AU - Chatila, Khaled
N1 - Funding Information:
This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors. The authors did not receive funding for this manuscript. No Rapid Service Fee was received by the journal for the publication of this article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Study Conception and Design: R.A.T., J.R.L., K.C. Manuscript Preparation/Drafting: R.A.T., J.R.L., P.R.L., A.M., U.R., W.K., K.C. Expert Review: P.R.L., A.M., U.R., W.K., K.C. Ravi A. Thakker, MD, Jorge Rodriguez Lozano, MD, Patricia Rodriguez Lozano, MD, Afaq Motiwala, MD, Umamahesh Rangasetty, MD, Wissam Khalife, MD, and Khaled Chatila, MD have nothing to disclose. Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/3
Y1 - 2022/3
N2 - Coronary microvascular disease or dysfunction (CMVD) has been associated with adverse cardiovascular outcomes. Despite a growing prevalence, guidelines on definitive treatment are lacking. Proposed mechanisms of endothelial dysfunction and resultant inflammation have been demonstrated as the underlying cause. Imaging modalities such as echocardiography, cardiac MRI, PET, and in some instances CT, have been shown to be useful in diagnosing CMVD mainly through assessment of coronary blood flow. Invasive measurements through thermodilution and pressure sensor-guided Doppler microcatheters have also been utilized. Treatment options are directed at targeting inflammatory pathways and angina. In our review, we highlight the current literature on the background of CMVD, diagnostic modalities, and management of this disease.
AB - Coronary microvascular disease or dysfunction (CMVD) has been associated with adverse cardiovascular outcomes. Despite a growing prevalence, guidelines on definitive treatment are lacking. Proposed mechanisms of endothelial dysfunction and resultant inflammation have been demonstrated as the underlying cause. Imaging modalities such as echocardiography, cardiac MRI, PET, and in some instances CT, have been shown to be useful in diagnosing CMVD mainly through assessment of coronary blood flow. Invasive measurements through thermodilution and pressure sensor-guided Doppler microcatheters have also been utilized. Treatment options are directed at targeting inflammatory pathways and angina. In our review, we highlight the current literature on the background of CMVD, diagnostic modalities, and management of this disease.
KW - Coronary microvascular disease
KW - Coronary microvascular dysfunction
KW - Non-obstructive coronary artery disease
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U2 - 10.1007/s40119-021-00250-6
DO - 10.1007/s40119-021-00250-6
M3 - Review article
AN - SCOPUS:85122381427
SN - 2193-8261
VL - 11
SP - 23
EP - 31
JO - Cardiology and Therapy
JF - Cardiology and Therapy
IS - 1
ER -