Coronary Microvascular Disease

Ravi A. Thakker, Jorge Rodriguez Lozano, Patricia Rodriguez Lozano, Afaq Motiwala, Umamahesh Rangasetty, Wissam Khalife, Khaled Chatila

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Coronary microvascular disease or dysfunction (CMVD) has been associated with adverse cardiovascular outcomes. Despite a growing prevalence, guidelines on definitive treatment are lacking. Proposed mechanisms of endothelial dysfunction and resultant inflammation have been demonstrated as the underlying cause. Imaging modalities such as echocardiography, cardiac MRI, PET, and in some instances CT, have been shown to be useful in diagnosing CMVD mainly through assessment of coronary blood flow. Invasive measurements through thermodilution and pressure sensor-guided Doppler microcatheters have also been utilized. Treatment options are directed at targeting inflammatory pathways and angina. In our review, we highlight the current literature on the background of CMVD, diagnostic modalities, and management of this disease.

Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalCardiology and Therapy
Issue number1
StatePublished - Mar 2022


  • Coronary microvascular disease
  • Coronary microvascular dysfunction
  • Non-obstructive coronary artery disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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