CoronaVac and ChAdOx1 Vaccination and Gamma Infection Elicited Neutralizing Antibodies against the SARS-CoV-2 Delta Variant

Marcilio Jorge Fumagalli, Luiza Antunes Castro-Jorge, William Marciel de Souza, Patrick Orestes de Azevedo, Alana Witt Hansen, Ricardo Tostes Gazzinelli, Benedito Antônio Lopes da Fonseca, Fernando Rosado Spilki, Luiz Tadeu Moraes Figueiredo

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The emergence of new SARS-CoV-2 variants represents a constant threat to world public health. The SARS-CoV-2 Delta variant was identified in late 2020 in India; since then, it has spread to many other countries, replacing other predominant lineages and raising concerns about vaccination efficiency. We evaluated the sensitivity of the Delta variant to antibodies elicited by COVID-19 vaccinated (CoronaVac and ChAdOx1) and convalescent individuals previously infected by earlier lineages and by the Gamma variant. No reduction in the neutralizing efficacy of the Delta variant was observed when compared to B lineage and a reduced neutralization was observed for the Gamma variant. Our results indicate that neutralization of the Delta variant is not compromised in individuals vaccinated by CoronaVac or ChAdOx1; however, a reduction in neutralization efficacy is expected for individuals infected by the Gamma variant, highlighting the importance of continuous vaccination even for previously infected individuals.

Original languageEnglish (US)
Article number305
JournalViruses
Volume14
Issue number2
DOIs
StatePublished - Feb 2022

Keywords

  • Antibodies
  • ChAdOx1
  • Convalescence
  • CoronaVac
  • Delta variant
  • Gamma variant
  • Neutralization
  • SARS-CoV-2
  • Vaccination

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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