@article{1f6e0187daf24085b4d1ea20a2721374,
title = "CoronaVac and ChAdOx1 Vaccination and Gamma Infection Elicited Neutralizing Antibodies against the SARS-CoV-2 Delta Variant",
abstract = "The emergence of new SARS-CoV-2 variants represents a constant threat to world public health. The SARS-CoV-2 Delta variant was identified in late 2020 in India; since then, it has spread to many other countries, replacing other predominant lineages and raising concerns about vaccination efficiency. We evaluated the sensitivity of the Delta variant to antibodies elicited by COVID-19 vaccinated (CoronaVac and ChAdOx1) and convalescent individuals previously infected by earlier lineages and by the Gamma variant. No reduction in the neutralizing efficacy of the Delta variant was observed when compared to B lineage and a reduced neutralization was observed for the Gamma variant. Our results indicate that neutralization of the Delta variant is not compromised in individuals vaccinated by CoronaVac or ChAdOx1; however, a reduction in neutralization efficacy is expected for individuals infected by the Gamma variant, highlighting the importance of continuous vaccination even for previously infected individuals.",
keywords = "Antibodies, ChAdOx1, Convalescence, CoronaVac, Delta variant, Gamma variant, Neutralization, SARS-CoV-2, Vaccination",
author = "Fumagalli, {Marcilio Jorge} and Castro-Jorge, {Luiza Antunes} and {de Souza}, {William Marciel} and {de Azevedo}, {Patrick Orestes} and Hansen, {Alana Witt} and Gazzinelli, {Ricardo Tostes} and {da Fonseca}, {Benedito Ant{\^o}nio Lopes} and Spilki, {Fernando Rosado} and Figueiredo, {Luiz Tadeu Moraes}",
note = "Funding Information: This research was funded by Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo (FAPESP), (grant numbers 2019/26119-0 (LTMF and BALF) and 2020/05527-0 (LTMF and RTG), and scholarship numbers 2018/09383-3 (MJF)). Rede Corona-{\^o}mica BR MCTI/FINEP affiliated to RedeV{\'i}rus/MCTI. Financiadora de estudos e projetos (FINEP, grant number 01.20.0029.000462/20) and Conselho Nacional de Desenvolvimento Cientifico e Tecnol{\'o}gico (CNPq, grant number 404096/2020-4). Funding Information: Funding: This research was funded by Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo (FAPESP), (grant numbers 2019/26119-0 (LTMF and BALF) and 2020/05527-0 (LTMF and RTG), and scholarship numbers 2018/09383-3 (MJF)). Rede Corona-{\^o}mica BR MCTI/FINEP affiliated to Re-deV{\'i}rus/MCTI. Financiadora de estudos e projetos (FINEP, grant number 01.20.0029.000462/20) and Conselho Nacional de Desenvolvimento Cientifico e Tecnol{\'o}gico (CNPq, grant number 404096/2020-4). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = feb,
doi = "10.3390/v14020305",
language = "English (US)",
volume = "14",
journal = "Viruses",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",
}