Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression

Krishna Narayanan, Sydney I. Ramirez, Kumari G. Lokugamage, Shinji Makino

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The recent emergence of two highly pathogenic human coronaviruses (CoVs), severe acute respiratory syndrome CoV and Middle East respiratory syndrome CoV, has ignited a strong interest in the identification of viral factors that determine the virulence and pathogenesis of CoVs. The nonstructural protein 1 (nsp1) of CoVs has attracted considerable attention in this regard as a potential virulence factor and a target for CoV vaccine development because of accumulating evidence that point to its role in the downregulation of host innate immune responses to CoV infection. Studies have revealed both functional conservation and mechanistic divergence among the nsp1 of different mammalian CoVs in perturbing host gene expression and antiviral responses. This review summarizes the current knowledge about the biological functions of CoV nsp1 that provides an insight into the novel strategies utilized by this viral protein to modulate host and viral gene expression during CoV infection.

Original languageEnglish (US)
Pages (from-to)89-100
Number of pages12
JournalVirus Research
Volume202
DOIs
StatePublished - Apr 16 2015

Fingerprint

Viral Gene Expression Regulation
Coronavirus
Virulence Factors
Coronavirus Infections
Gene Expression
Severe Acute Respiratory Syndrome
Viral Genes
Viral Proteins
Infection
Innate Immunity
Antiviral Agents
Proteins
Down-Regulation
Vaccines
coronavirus nonstructural protein

Keywords

  • Coronavirus
  • MRNA cleavage
  • Nsp1
  • RNA viruses
  • SARS
  • Translation inhibition

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Cancer Research

Cite this

Coronavirus nonstructural protein 1 : Common and distinct functions in the regulation of host and viral gene expression. / Narayanan, Krishna; Ramirez, Sydney I.; Lokugamage, Kumari G.; Makino, Shinji.

In: Virus Research, Vol. 202, 16.04.2015, p. 89-100.

Research output: Contribution to journalArticle

Narayanan, Krishna ; Ramirez, Sydney I. ; Lokugamage, Kumari G. ; Makino, Shinji. / Coronavirus nonstructural protein 1 : Common and distinct functions in the regulation of host and viral gene expression. In: Virus Research. 2015 ; Vol. 202. pp. 89-100.
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