Correlation between CT-based measured renal volumes and nuclear-renography-based split renal function in living kidney donors. Clinical diagnostic utility and practice patterns

Alejandro Diez, John Powelson, Chandru P. Sundaram, Tim E. Taber, Muhammad A. Mujtaba, Muhammad S. Yaqub, Dennis P. Mishler, William C. Goggins, Asif A. Sharfuddin

Research output: Contribution to journalArticle

14 Scopus citations


Introduction: Living donor evaluation involves imaging to determine the choice of kidney for nephrectomy. Our aim was to study the diagnostic accuracy and correlation between CT-based volume measurements and split renal function (SRF) as measured by nuclear renography in potential living donors and its impact on kidney selection decision. Methods: We analyzed 190 CT-based volume measurements in healthy donors, of which 65 donors had a radionuclide study performed to determine SRF. Results: There were no differences in demographics, anthropometric measurements, total volumes, eGFR, creatinine clearances between those who required a nuclear scan and those who did not. There was a significant correlation between CT-volume-measurement-based SRF and nuclear-scan-based SRF (Pearson coefficient r 0.59; p < 0.001). Furthermore, selective nuclear-based SRF allowed careful selection of donor nephrectomy, leaving the donor with the higher functioning kidney in most cases. There was also a significantly higher number of right-sided nephrectomies selected after nuclear-based SRF studies. Conclusion: CT-based volume measurements in living donor imaging have sufficient correlation with nuclear-based SRF. Selective use of nuclear-scan-based SRF allows careful selection for donor nephrectomy.

Original languageEnglish (US)
Pages (from-to)675-682
Number of pages8
JournalClinical Transplantation
Issue number6
StatePublished - Jun 2014
Externally publishedYes



  • CT
  • Kidney transplantation
  • Kidney volume
  • Living donor
  • Nuclear renography
  • Split renal function

ASJC Scopus subject areas

  • Transplantation

Cite this