Correlation between optical coherence tomography images and histology of pigskin

Roman Kuranov, Veronika Sapozhnikova, Donald Prough, Inga Cicenaite, Rinat Esenaliev

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Noninvasive imaging techniques such as optical coherence tomography (OCT) are being widely used for early diagnostics of a variety of pathologies. Traditional tissue preparation for histological evaluation alters the dimensions of histological images such that differences between the dimensions of histologic and OCT images can be as great as 2.5-fold. This discrepancy complicates quantitative interpretation of OCT images. Here we used a steel ring sewn to the pigskin to avoid tissue deformation due to excision and fixation and used a surgical suture as a fixed tissue marker. With these techniques, we achieved good correlation between OCT and histological images with differences of less than 10%. The resulting method significantly enhances the diagnostic capabilities of the OCT technique.

Original languageEnglish (US)
Pages (from-to)1782-1786
Number of pages5
JournalApplied Optics
Volume46
Issue number10
DOIs
StatePublished - Apr 1 2007

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ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

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