Correlation Between PaO2/FIO2 and Peripheral Capillary Oxygenation/FIO2 in Burned Children With Smoke Inhalation Injury

Janos Cambiaso-Daniel, Charles D. Voigt, Eric Rivas, Gabriel Hundeshagen, Omar Nunez-Lopez, Lars Peter Kamolz, Michaela Sljivich, Linda Sousse, David Herndon, Oscar Suman, Michael Kinsky, Ronald P. Mlcak

Research output: Contribution to journalArticle

Abstract

OBJECTIVES:: Determine whether the peripheral capillary oxygenation/FIO2 ratio correlates with the PaO2/FIO2 ratio in burned children with smoke inhalation injury, with the goal of understanding if the peripheral capillary oxygenation/FIO2 ratio can serve as a surrogate for the PaO2/FIO2 ratio for the diagnosis of acute respiratory distress syndrome. DESIGN:: Retrospective chart review. SETTING:: Shriners Hospitals for Children—Galveston. PATIENTS:: All burned children with smoke inhalation injury who were admitted from 1996 to 2014 and had simultaneously obtained peripheral capillary oxygenation, FIO2 and PaO2 measurements. INTERVENTIONS:: None. MEASUREMENTS AND MAIN RESULTS:: Two hundred seventy-three patients (63% male, 8 ± 5 yr, 53% ± 24% total body surface area burns) were analyzed. Peripheral capillary oxygenation/FIO2 ratios were divided into four subgroups based on peripheral capillary oxygenation values (≤ 100%, ≤ 98%, ≤ 95%, and ≤ 92%). Significance was accepted at r greater than 0.81. The r (number of matches) was 0.66 (23,072) for less than or equal to 100%, 0.87 (18,932) for less than or equal to 98%, 0.89 (7,056) for less than or equal to 95%, and 0.93 (4,229) for less than or equal to 92%. In the subgroup of patients who developed acute respiratory distress syndrome, r was 0.65 (8,357) for less than or equal to 100%, 0.89 (7,578) for less than or equal to 98%, 0.89 (4,115) for less than or equal to 95%, and 0.91 (2,288) less than or equal to 92%. CONCLUSIONS:: PaO2/FIO2 and peripheral capillary oxygenation/FIO2 strongly correlate in burned children with smoke inhalation injury, with a peripheral capillary oxygenation of less than 92% providing the strongest correlation. Thus, peripheral capillary oxygenation/FIO2 ratio may be able to serve as surrogate for PaO2/FIO2, especially when titrating FIO2 to achieve a peripheral capillary oxygenation of 90–95% (i.e., in the acute respiratory distress syndrome range).

Original languageEnglish (US)
JournalPediatric Critical Care Medicine
DOIs
StateAccepted/In press - Jul 18 2017

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Smoke Inhalation Injury
Adult Respiratory Distress Syndrome
Body Surface Area
Burns

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Critical Care and Intensive Care Medicine

Cite this

Cambiaso-Daniel, J., Voigt, C. D., Rivas, E., Hundeshagen, G., Nunez-Lopez, O., Kamolz, L. P., ... Mlcak, R. P. (Accepted/In press). Correlation Between PaO2/FIO2 and Peripheral Capillary Oxygenation/FIO2 in Burned Children With Smoke Inhalation Injury. Pediatric Critical Care Medicine. https://doi.org/10.1097/PCC.0000000000001287

Correlation Between PaO2/FIO2 and Peripheral Capillary Oxygenation/FIO2 in Burned Children With Smoke Inhalation Injury. / Cambiaso-Daniel, Janos; Voigt, Charles D.; Rivas, Eric; Hundeshagen, Gabriel; Nunez-Lopez, Omar; Kamolz, Lars Peter; Sljivich, Michaela; Sousse, Linda; Herndon, David; Suman, Oscar; Kinsky, Michael; Mlcak, Ronald P.

In: Pediatric Critical Care Medicine, 18.07.2017.

Research output: Contribution to journalArticle

Cambiaso-Daniel, Janos ; Voigt, Charles D. ; Rivas, Eric ; Hundeshagen, Gabriel ; Nunez-Lopez, Omar ; Kamolz, Lars Peter ; Sljivich, Michaela ; Sousse, Linda ; Herndon, David ; Suman, Oscar ; Kinsky, Michael ; Mlcak, Ronald P. / Correlation Between PaO2/FIO2 and Peripheral Capillary Oxygenation/FIO2 in Burned Children With Smoke Inhalation Injury. In: Pediatric Critical Care Medicine. 2017.
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abstract = "OBJECTIVES:: Determine whether the peripheral capillary oxygenation/FIO2 ratio correlates with the PaO2/FIO2 ratio in burned children with smoke inhalation injury, with the goal of understanding if the peripheral capillary oxygenation/FIO2 ratio can serve as a surrogate for the PaO2/FIO2 ratio for the diagnosis of acute respiratory distress syndrome. DESIGN:: Retrospective chart review. SETTING:: Shriners Hospitals for Children—Galveston. PATIENTS:: All burned children with smoke inhalation injury who were admitted from 1996 to 2014 and had simultaneously obtained peripheral capillary oxygenation, FIO2 and PaO2 measurements. INTERVENTIONS:: None. MEASUREMENTS AND MAIN RESULTS:: Two hundred seventy-three patients (63{\%} male, 8 ± 5 yr, 53{\%} ± 24{\%} total body surface area burns) were analyzed. Peripheral capillary oxygenation/FIO2 ratios were divided into four subgroups based on peripheral capillary oxygenation values (≤ 100{\%}, ≤ 98{\%}, ≤ 95{\%}, and ≤ 92{\%}). Significance was accepted at r greater than 0.81. The r (number of matches) was 0.66 (23,072) for less than or equal to 100{\%}, 0.87 (18,932) for less than or equal to 98{\%}, 0.89 (7,056) for less than or equal to 95{\%}, and 0.93 (4,229) for less than or equal to 92{\%}. In the subgroup of patients who developed acute respiratory distress syndrome, r was 0.65 (8,357) for less than or equal to 100{\%}, 0.89 (7,578) for less than or equal to 98{\%}, 0.89 (4,115) for less than or equal to 95{\%}, and 0.91 (2,288) less than or equal to 92{\%}. CONCLUSIONS:: PaO2/FIO2 and peripheral capillary oxygenation/FIO2 strongly correlate in burned children with smoke inhalation injury, with a peripheral capillary oxygenation of less than 92{\%} providing the strongest correlation. Thus, peripheral capillary oxygenation/FIO2 ratio may be able to serve as surrogate for PaO2/FIO2, especially when titrating FIO2 to achieve a peripheral capillary oxygenation of 90–95{\%} (i.e., in the acute respiratory distress syndrome range).",
author = "Janos Cambiaso-Daniel and Voigt, {Charles D.} and Eric Rivas and Gabriel Hundeshagen and Omar Nunez-Lopez and Kamolz, {Lars Peter} and Michaela Sljivich and Linda Sousse and David Herndon and Oscar Suman and Michael Kinsky and Mlcak, {Ronald P.}",
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T1 - Correlation Between PaO2/FIO2 and Peripheral Capillary Oxygenation/FIO2 in Burned Children With Smoke Inhalation Injury

AU - Cambiaso-Daniel, Janos

AU - Voigt, Charles D.

AU - Rivas, Eric

AU - Hundeshagen, Gabriel

AU - Nunez-Lopez, Omar

AU - Kamolz, Lars Peter

AU - Sljivich, Michaela

AU - Sousse, Linda

AU - Herndon, David

AU - Suman, Oscar

AU - Kinsky, Michael

AU - Mlcak, Ronald P.

PY - 2017/7/18

Y1 - 2017/7/18

N2 - OBJECTIVES:: Determine whether the peripheral capillary oxygenation/FIO2 ratio correlates with the PaO2/FIO2 ratio in burned children with smoke inhalation injury, with the goal of understanding if the peripheral capillary oxygenation/FIO2 ratio can serve as a surrogate for the PaO2/FIO2 ratio for the diagnosis of acute respiratory distress syndrome. DESIGN:: Retrospective chart review. SETTING:: Shriners Hospitals for Children—Galveston. PATIENTS:: All burned children with smoke inhalation injury who were admitted from 1996 to 2014 and had simultaneously obtained peripheral capillary oxygenation, FIO2 and PaO2 measurements. INTERVENTIONS:: None. MEASUREMENTS AND MAIN RESULTS:: Two hundred seventy-three patients (63% male, 8 ± 5 yr, 53% ± 24% total body surface area burns) were analyzed. Peripheral capillary oxygenation/FIO2 ratios were divided into four subgroups based on peripheral capillary oxygenation values (≤ 100%, ≤ 98%, ≤ 95%, and ≤ 92%). Significance was accepted at r greater than 0.81. The r (number of matches) was 0.66 (23,072) for less than or equal to 100%, 0.87 (18,932) for less than or equal to 98%, 0.89 (7,056) for less than or equal to 95%, and 0.93 (4,229) for less than or equal to 92%. In the subgroup of patients who developed acute respiratory distress syndrome, r was 0.65 (8,357) for less than or equal to 100%, 0.89 (7,578) for less than or equal to 98%, 0.89 (4,115) for less than or equal to 95%, and 0.91 (2,288) less than or equal to 92%. CONCLUSIONS:: PaO2/FIO2 and peripheral capillary oxygenation/FIO2 strongly correlate in burned children with smoke inhalation injury, with a peripheral capillary oxygenation of less than 92% providing the strongest correlation. Thus, peripheral capillary oxygenation/FIO2 ratio may be able to serve as surrogate for PaO2/FIO2, especially when titrating FIO2 to achieve a peripheral capillary oxygenation of 90–95% (i.e., in the acute respiratory distress syndrome range).

AB - OBJECTIVES:: Determine whether the peripheral capillary oxygenation/FIO2 ratio correlates with the PaO2/FIO2 ratio in burned children with smoke inhalation injury, with the goal of understanding if the peripheral capillary oxygenation/FIO2 ratio can serve as a surrogate for the PaO2/FIO2 ratio for the diagnosis of acute respiratory distress syndrome. DESIGN:: Retrospective chart review. SETTING:: Shriners Hospitals for Children—Galveston. PATIENTS:: All burned children with smoke inhalation injury who were admitted from 1996 to 2014 and had simultaneously obtained peripheral capillary oxygenation, FIO2 and PaO2 measurements. INTERVENTIONS:: None. MEASUREMENTS AND MAIN RESULTS:: Two hundred seventy-three patients (63% male, 8 ± 5 yr, 53% ± 24% total body surface area burns) were analyzed. Peripheral capillary oxygenation/FIO2 ratios were divided into four subgroups based on peripheral capillary oxygenation values (≤ 100%, ≤ 98%, ≤ 95%, and ≤ 92%). Significance was accepted at r greater than 0.81. The r (number of matches) was 0.66 (23,072) for less than or equal to 100%, 0.87 (18,932) for less than or equal to 98%, 0.89 (7,056) for less than or equal to 95%, and 0.93 (4,229) for less than or equal to 92%. In the subgroup of patients who developed acute respiratory distress syndrome, r was 0.65 (8,357) for less than or equal to 100%, 0.89 (7,578) for less than or equal to 98%, 0.89 (4,115) for less than or equal to 95%, and 0.91 (2,288) less than or equal to 92%. CONCLUSIONS:: PaO2/FIO2 and peripheral capillary oxygenation/FIO2 strongly correlate in burned children with smoke inhalation injury, with a peripheral capillary oxygenation of less than 92% providing the strongest correlation. Thus, peripheral capillary oxygenation/FIO2 ratio may be able to serve as surrogate for PaO2/FIO2, especially when titrating FIO2 to achieve a peripheral capillary oxygenation of 90–95% (i.e., in the acute respiratory distress syndrome range).

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