Correlation between Pao2/Fio2 and peripheral capillary oxygenation/Fio2 in burned children with smoke inhalation injury

Janos Cambiaso-Daniel; Charles D. Voigt; Eric Rivas; Gabriel Hundeshagen; Omar Nunez-Lopez; Lars Peter Kamolz; Michaela Sljivich; Linda E. Sousse; David N. Herndon; Oscar E. Suman; Michael P. Kinsky; Ronald P. Mlcak

doi:10.1097/PCC.0000000000001287

Correlation between Pao₂/Fio₂ and peripheral capillary oxygenation/Fio₂ in burned children with smoke inhalation injury

Janos Cambiaso-Daniel, Charles D. Voigt, Eric Rivas, Gabriel Hundeshagen, Omar Nunez-Lopez, Lars Peter Kamolz, Michaela Sljivich, Linda E. Sousse, David N. Herndon, Oscar E. Suman, Michael P. Kinsky, Ronald P. Mlcak

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Objectives: Determine whether the peripheral capillary oxygenation/Fio₂ ratio correlates with the Pao₂/Fio₂ ratio in burned children with smoke inhalation injury, with the goal of understanding if the peripheral capillary oxygenation/Fio₂ ratio can serve as a surrogate for the Pao₂/Fio₂ ratio for the diagnosis of acute respiratory distress syndrome. Design: Retrospective chart review. Setting: Shriners Hospitals for Children - Galveston. Patients: All burned children with smoke inhalation injury who were admitted from 1996 to 2014 and had simultaneously obtained peripheral capillary oxygenation, Fio₂ and Pao₂ measurements. Interventions: None. Measurements and Main Results: Two hundred seventy-three patients (63% male, 8 ± 5 yr, 53% ± 24% total body surface area burns) were analyzed. Peripheral capillary oxygenation/Fio₂ ratios were divided into four subgroups based on peripheral capillary oxygenation values (≤ 100%, ≤ 98%, ≤ 95%, and ≤ 92%). Significance was accepted at r² greater than 0.81. The r² (number of matches) was 0.66 (23,072) for less than or equal to 100%, 0.87 (18,932) for less than or equal to 98%, 0.89 (7,056) for less than or equal to 95%, and 0.93 (4,229) for less than or equal to 92%. In the subgroup of patients who developed acute respiratory distress syndrome, r² was 0.65 (8,357) for less than or equal to 100%, 0.89 (7,578) for less than or equal to 98%, 0.89 (4,115) for less than or equal to 95%, and 0.91 (2,288) less than or equal to 92%. Conclusions: Pao₂/Fio₂ and peripheral capillary oxygenation/Fio₂ strongly correlate in burned children with smoke inhalation injury, with a peripheral capillary oxygenation of less than 92% providing the strongest correlation. Thus, peripheral capillary oxygenation/Fio₂ ratio may be able to serve as surrogate for Pao₂/Fio₂, especially when titrating Fio₂ to achieve a peripheral capillary oxygenation of 90-95% (i.e., in the acute respiratory distress syndrome range).

Original language	English (US)
Pages (from-to)	e472-e476
Journal	Pediatric Critical Care Medicine
Volume	18
Issue number	10
DOIs	https://doi.org/10.1097/PCC.0000000000001287
State	Published - Oct 1 2017

Keywords

Acute lung injury
Acute respiratory distress syndrome
Critical care
Pediatric Acute Lung Injury Consensus Conference
Trauma

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Critical Care and Intensive Care Medicine

Access to Document

10.1097/PCC.0000000000001287

Cite this

Cambiaso-Daniel, J., Voigt, C. D., Rivas, E., Hundeshagen, G., Nunez-Lopez, O., Kamolz, L. P., Sljivich, M., Sousse, L. E., Herndon, D. N., Suman, O. E., Kinsky, M. P., & Mlcak, R. P. (2017). Correlation between Pao₂/Fio₂ and peripheral capillary oxygenation/Fio₂ in burned children with smoke inhalation injury. Pediatric Critical Care Medicine, 18(10), e472-e476. https://doi.org/10.1097/PCC.0000000000001287

Cambiaso-Daniel, J, Voigt, CD, Rivas, E, Hundeshagen, G, Nunez-Lopez, O, Kamolz, LP, Sljivich, M, Sousse, LE, Herndon, DN, Suman, OE , Kinsky, MP & Mlcak, RP 2017, 'Correlation between Pao₂/Fio₂ and peripheral capillary oxygenation/Fio₂ in burned children with smoke inhalation injury', Pediatric Critical Care Medicine, vol. 18, no. 10, pp. e472-e476. https://doi.org/10.1097/PCC.0000000000001287

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title = "Correlation between Pao2/Fio2 and peripheral capillary oxygenation/Fio2 in burned children with smoke inhalation injury",

abstract = "Objectives: Determine whether the peripheral capillary oxygenation/Fio2 ratio correlates with the Pao2/Fio2 ratio in burned children with smoke inhalation injury, with the goal of understanding if the peripheral capillary oxygenation/Fio2 ratio can serve as a surrogate for the Pao2/Fio2 ratio for the diagnosis of acute respiratory distress syndrome. Design: Retrospective chart review. Setting: Shriners Hospitals for Children - Galveston. Patients: All burned children with smoke inhalation injury who were admitted from 1996 to 2014 and had simultaneously obtained peripheral capillary oxygenation, Fio2 and Pao2 measurements. Interventions: None. Measurements and Main Results: Two hundred seventy-three patients (63% male, 8 ± 5 yr, 53% ± 24% total body surface area burns) were analyzed. Peripheral capillary oxygenation/Fio2 ratios were divided into four subgroups based on peripheral capillary oxygenation values (≤ 100%, ≤ 98%, ≤ 95%, and ≤ 92%). Significance was accepted at r2 greater than 0.81. The r2 (number of matches) was 0.66 (23,072) for less than or equal to 100%, 0.87 (18,932) for less than or equal to 98%, 0.89 (7,056) for less than or equal to 95%, and 0.93 (4,229) for less than or equal to 92%. In the subgroup of patients who developed acute respiratory distress syndrome, r2 was 0.65 (8,357) for less than or equal to 100%, 0.89 (7,578) for less than or equal to 98%, 0.89 (4,115) for less than or equal to 95%, and 0.91 (2,288) less than or equal to 92%. Conclusions: Pao2/Fio2 and peripheral capillary oxygenation/Fio2 strongly correlate in burned children with smoke inhalation injury, with a peripheral capillary oxygenation of less than 92% providing the strongest correlation. Thus, peripheral capillary oxygenation/Fio2 ratio may be able to serve as surrogate for Pao2/Fio2, especially when titrating Fio2 to achieve a peripheral capillary oxygenation of 90-95% (i.e., in the acute respiratory distress syndrome range).",

keywords = "Acute lung injury, Acute respiratory distress syndrome, Critical care, Pediatric Acute Lung Injury Consensus Conference, Trauma",

author = "Janos Cambiaso-Daniel and Voigt, {Charles D.} and Eric Rivas and Gabriel Hundeshagen and Omar Nunez-Lopez and Kamolz, {Lars Peter} and Michaela Sljivich and Sousse, {Linda E.} and Herndon, {David N.} and Suman, {Oscar E.} and Kinsky, {Michael P.} and Mlcak, {Ronald P.}",

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doi = "10.1097/PCC.0000000000001287",

language = "English (US)",

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T1 - Correlation between Pao2/Fio2 and peripheral capillary oxygenation/Fio2 in burned children with smoke inhalation injury

AU - Cambiaso-Daniel, Janos

AU - Voigt, Charles D.

AU - Rivas, Eric

AU - Hundeshagen, Gabriel

AU - Nunez-Lopez, Omar

AU - Kamolz, Lars Peter

AU - Sljivich, Michaela

AU - Sousse, Linda E.

AU - Herndon, David N.

AU - Suman, Oscar E.

AU - Kinsky, Michael P.

AU - Mlcak, Ronald P.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Objectives: Determine whether the peripheral capillary oxygenation/Fio2 ratio correlates with the Pao2/Fio2 ratio in burned children with smoke inhalation injury, with the goal of understanding if the peripheral capillary oxygenation/Fio2 ratio can serve as a surrogate for the Pao2/Fio2 ratio for the diagnosis of acute respiratory distress syndrome. Design: Retrospective chart review. Setting: Shriners Hospitals for Children - Galveston. Patients: All burned children with smoke inhalation injury who were admitted from 1996 to 2014 and had simultaneously obtained peripheral capillary oxygenation, Fio2 and Pao2 measurements. Interventions: None. Measurements and Main Results: Two hundred seventy-three patients (63% male, 8 ± 5 yr, 53% ± 24% total body surface area burns) were analyzed. Peripheral capillary oxygenation/Fio2 ratios were divided into four subgroups based on peripheral capillary oxygenation values (≤ 100%, ≤ 98%, ≤ 95%, and ≤ 92%). Significance was accepted at r2 greater than 0.81. The r2 (number of matches) was 0.66 (23,072) for less than or equal to 100%, 0.87 (18,932) for less than or equal to 98%, 0.89 (7,056) for less than or equal to 95%, and 0.93 (4,229) for less than or equal to 92%. In the subgroup of patients who developed acute respiratory distress syndrome, r2 was 0.65 (8,357) for less than or equal to 100%, 0.89 (7,578) for less than or equal to 98%, 0.89 (4,115) for less than or equal to 95%, and 0.91 (2,288) less than or equal to 92%. Conclusions: Pao2/Fio2 and peripheral capillary oxygenation/Fio2 strongly correlate in burned children with smoke inhalation injury, with a peripheral capillary oxygenation of less than 92% providing the strongest correlation. Thus, peripheral capillary oxygenation/Fio2 ratio may be able to serve as surrogate for Pao2/Fio2, especially when titrating Fio2 to achieve a peripheral capillary oxygenation of 90-95% (i.e., in the acute respiratory distress syndrome range).

AB - Objectives: Determine whether the peripheral capillary oxygenation/Fio2 ratio correlates with the Pao2/Fio2 ratio in burned children with smoke inhalation injury, with the goal of understanding if the peripheral capillary oxygenation/Fio2 ratio can serve as a surrogate for the Pao2/Fio2 ratio for the diagnosis of acute respiratory distress syndrome. Design: Retrospective chart review. Setting: Shriners Hospitals for Children - Galveston. Patients: All burned children with smoke inhalation injury who were admitted from 1996 to 2014 and had simultaneously obtained peripheral capillary oxygenation, Fio2 and Pao2 measurements. Interventions: None. Measurements and Main Results: Two hundred seventy-three patients (63% male, 8 ± 5 yr, 53% ± 24% total body surface area burns) were analyzed. Peripheral capillary oxygenation/Fio2 ratios were divided into four subgroups based on peripheral capillary oxygenation values (≤ 100%, ≤ 98%, ≤ 95%, and ≤ 92%). Significance was accepted at r2 greater than 0.81. The r2 (number of matches) was 0.66 (23,072) for less than or equal to 100%, 0.87 (18,932) for less than or equal to 98%, 0.89 (7,056) for less than or equal to 95%, and 0.93 (4,229) for less than or equal to 92%. In the subgroup of patients who developed acute respiratory distress syndrome, r2 was 0.65 (8,357) for less than or equal to 100%, 0.89 (7,578) for less than or equal to 98%, 0.89 (4,115) for less than or equal to 95%, and 0.91 (2,288) less than or equal to 92%. Conclusions: Pao2/Fio2 and peripheral capillary oxygenation/Fio2 strongly correlate in burned children with smoke inhalation injury, with a peripheral capillary oxygenation of less than 92% providing the strongest correlation. Thus, peripheral capillary oxygenation/Fio2 ratio may be able to serve as surrogate for Pao2/Fio2, especially when titrating Fio2 to achieve a peripheral capillary oxygenation of 90-95% (i.e., in the acute respiratory distress syndrome range).

KW - Acute lung injury

KW - Acute respiratory distress syndrome

KW - Critical care

KW - Pediatric Acute Lung Injury Consensus Conference

KW - Trauma

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