Correlation between the number of placental opioid receptors, mode of delivery, and maternal narcotic use

Mahmoud Ahmed, Jay S. Schinfeld, R. Jones, A. G. Cavinato, C. Baker

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Human placental opioid receptors were assayed using the radioactive opioid agonist, etorphine, to determine the number of binding sites in villous tissue membrane preparations. Significant differences in receptor concentration per milligram of protein of tissue were found between placentas obtained following vaginal or abdominal delivery (P < 0.002). Labor itself did not alter apparent receptor numbers. In patients with maternal narcotic abuse during pregnancy, no opioid binding could be detected regardless of the mode of delivery, suggesting possible receptor down-regulation.

Original languageEnglish (US)
Pages (from-to)255-267
Number of pages13
JournalMolecular Membrane Biology
Volume6
Issue number3
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Narcotics
Opioid Receptors
Opioid Analgesics
Etorphine
Mothers
Tissue
Opioid-Related Disorders
Cesarean Section
Placenta
Down-Regulation
Binding Sites
Personnel
Membranes
Pregnancy
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Cite this

Correlation between the number of placental opioid receptors, mode of delivery, and maternal narcotic use. / Ahmed, Mahmoud; Schinfeld, Jay S.; Jones, R.; Cavinato, A. G.; Baker, C.

In: Molecular Membrane Biology, Vol. 6, No. 3, 1986, p. 255-267.

Research output: Contribution to journalArticle

Ahmed, Mahmoud ; Schinfeld, Jay S. ; Jones, R. ; Cavinato, A. G. ; Baker, C. / Correlation between the number of placental opioid receptors, mode of delivery, and maternal narcotic use. In: Molecular Membrane Biology. 1986 ; Vol. 6, No. 3. pp. 255-267.
@article{6d97034aa8be4a9d8ce8a8a6b734b2c8,
title = "Correlation between the number of placental opioid receptors, mode of delivery, and maternal narcotic use",
abstract = "Human placental opioid receptors were assayed using the radioactive opioid agonist, etorphine, to determine the number of binding sites in villous tissue membrane preparations. Significant differences in receptor concentration per milligram of protein of tissue were found between placentas obtained following vaginal or abdominal delivery (P < 0.002). Labor itself did not alter apparent receptor numbers. In patients with maternal narcotic abuse during pregnancy, no opioid binding could be detected regardless of the mode of delivery, suggesting possible receptor down-regulation.",
author = "Mahmoud Ahmed and Schinfeld, {Jay S.} and R. Jones and Cavinato, {A. G.} and C. Baker",
year = "1986",
doi = "10.3109/09687688609065452",
language = "English (US)",
volume = "6",
pages = "255--267",
journal = "Molecular Membrane Biology",
issn = "0968-7688",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Correlation between the number of placental opioid receptors, mode of delivery, and maternal narcotic use

AU - Ahmed, Mahmoud

AU - Schinfeld, Jay S.

AU - Jones, R.

AU - Cavinato, A. G.

AU - Baker, C.

PY - 1986

Y1 - 1986

N2 - Human placental opioid receptors were assayed using the radioactive opioid agonist, etorphine, to determine the number of binding sites in villous tissue membrane preparations. Significant differences in receptor concentration per milligram of protein of tissue were found between placentas obtained following vaginal or abdominal delivery (P < 0.002). Labor itself did not alter apparent receptor numbers. In patients with maternal narcotic abuse during pregnancy, no opioid binding could be detected regardless of the mode of delivery, suggesting possible receptor down-regulation.

AB - Human placental opioid receptors were assayed using the radioactive opioid agonist, etorphine, to determine the number of binding sites in villous tissue membrane preparations. Significant differences in receptor concentration per milligram of protein of tissue were found between placentas obtained following vaginal or abdominal delivery (P < 0.002). Labor itself did not alter apparent receptor numbers. In patients with maternal narcotic abuse during pregnancy, no opioid binding could be detected regardless of the mode of delivery, suggesting possible receptor down-regulation.

UR - http://www.scopus.com/inward/record.url?scp=0022895065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022895065&partnerID=8YFLogxK

U2 - 10.3109/09687688609065452

DO - 10.3109/09687688609065452

M3 - Article

VL - 6

SP - 255

EP - 267

JO - Molecular Membrane Biology

JF - Molecular Membrane Biology

SN - 0968-7688

IS - 3

ER -