Correlation of neurological manifestations and MR images in a patient with Wilson's disease after liver transplantation

J. C. Wu, C. C. Huang, L. B. Jeng, N. S. Chu

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Orthotopic liver transplantation (OLT) has been applied to patients with Wilson's disease (WD) for correction of irreversible liver cirrhosis. However, the neurological outcome and the correlation between clinical manifestations and neuroimage findings after OLT remain uncertain. We present a WD patient who showed an improvement in both liver functions and neurological manifestations after OLT. Serum levels of ceruloplasmin and copper returned to normal rapidly after the operation. His ataxic gait was improved 5 months later and dysmetria and tremor disappeared 11 months later. The high signal intensities on T2-weighted brain magnetic resonance images regressed at bilateral thalami 5 months later and disappeared in bilateral thalami and red nuclei 16 months after OLT. We conclude that the neurological improvement could be expected in WD patients after OLT. The improvement was correlated with the MRI changes in red nuclei and bilateral thalami.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalActa Neurologica Scandinavica
Volume102
Issue number2
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Hepatolenticular degeneration
  • Liver transplantation
  • MRI
  • Wilson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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