Correlation of severity of coronary artery disease with insulin resistance

Mukund Prathivadibhayankaram, Padmanabh K. Kamath, Poornima A. Manjrekar, B. Unnikrishnan, Aishwarya Ullal, Mohammed Faheem Kotekar, Chakrapani Mahabala

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Insulin resistance (IR) has known to be associated with coronary artery disease (CAD), but the assessment of severity of the CAD based on IR in type 2 diabetes mellitus has not been established in detail. Aims: The aim of our study was to establish the correlation between IR and the severity of CAD in type 2 diabetes mellitus. Materials and Methods: In a cross-sectional study design, 61 consecutive patients with type 2 diabetes mellitus who underwent coronary angiogram for the evaluation of CAD were recruited. Fasting blood glucose, fasting insulin levels, systolic blood pressure and total cholesterol/high density lipoprotein-cholesterol ratio were determined. Homeostasis model assessment-IR (HOMA-IR) was correlated with severity of CAD, which was measured by modified Gensini Score. Results: There was a significant correlation between log HOMA-IR and severity of CAD (r = 0.303, P = 0.009) in diabetic patients. Correlation of the Gensini Score with other known risk factors was not significant. Conclusions: The results of our study indicate that we might able to predict the severity of CAD by measure of IR.

Original languageEnglish (US)
Pages (from-to)611-614
Number of pages4
JournalNorth American Journal of Medical Sciences
Volume5
Issue number10
StatePublished - Oct 1 2013
Externally publishedYes

Fingerprint

Insulin Resistance
Coronary Artery Disease
Type 2 Diabetes Mellitus
Fasting
Homeostasis
Blood Pressure
HDL Cholesterol
Blood Glucose
Angiography
Cross-Sectional Studies
Cholesterol
Insulin

Keywords

  • Coronary artery disease
  • Insulin resistance
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prathivadibhayankaram, M., Kamath, P. K., Manjrekar, P. A., Unnikrishnan, B., Ullal, A., Kotekar, M. F., & Mahabala, C. (2013). Correlation of severity of coronary artery disease with insulin resistance. North American Journal of Medical Sciences, 5(10), 611-614.

Correlation of severity of coronary artery disease with insulin resistance. / Prathivadibhayankaram, Mukund; Kamath, Padmanabh K.; Manjrekar, Poornima A.; Unnikrishnan, B.; Ullal, Aishwarya; Kotekar, Mohammed Faheem; Mahabala, Chakrapani.

In: North American Journal of Medical Sciences, Vol. 5, No. 10, 01.10.2013, p. 611-614.

Research output: Contribution to journalArticle

Prathivadibhayankaram, M, Kamath, PK, Manjrekar, PA, Unnikrishnan, B, Ullal, A, Kotekar, MF & Mahabala, C 2013, 'Correlation of severity of coronary artery disease with insulin resistance', North American Journal of Medical Sciences, vol. 5, no. 10, pp. 611-614.
Prathivadibhayankaram M, Kamath PK, Manjrekar PA, Unnikrishnan B, Ullal A, Kotekar MF et al. Correlation of severity of coronary artery disease with insulin resistance. North American Journal of Medical Sciences. 2013 Oct 1;5(10):611-614.
Prathivadibhayankaram, Mukund ; Kamath, Padmanabh K. ; Manjrekar, Poornima A. ; Unnikrishnan, B. ; Ullal, Aishwarya ; Kotekar, Mohammed Faheem ; Mahabala, Chakrapani. / Correlation of severity of coronary artery disease with insulin resistance. In: North American Journal of Medical Sciences. 2013 ; Vol. 5, No. 10. pp. 611-614.
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