Correlation of severity of human tick-borne encephalitis virus disease and pathogenicity in mice

Chaitanya Kurhade, Sarah Schreier, Yi Ping Lee, Loreen Zegenhagen, Marika Hjertqvist, Gerhard Dobler, Andrea Kröger, Anna K. Överby

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis.

Original languageEnglish (US)
Pages (from-to)1709-1712
Number of pages4
JournalEmerging infectious diseases
Volume24
Issue number9
DOIs
StatePublished - Sep 2018
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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