Correlations between major risk factors and closely related Mycobacterium tuberculosis isolates grouped by three current genotyping procedures: A population-based study in northeast Mexico

Katia Peñuelas-Urquides, Herminia Guadalupe Martínez-Rodríguez, José Antonio Enciso-Moreno, Gloria MaríA Molina-Salinas, Beatriz Silva-Ramírez, Gerardo Raymundo Padilla-Rivas, Lucio Vera-Cabrera, VíCtor Manuel Torres-De-La-Cruz, Yazmin Berenice Martínez-Martínez, Jorge Luis Ortega-García, Elsa Nancy Garza-Treviño, Leonor Enciso-Moreno, Odila Saucedo-Cárdenas, Pola Becerril-Montes, Salvador Said-Fernández

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The characteristics of tuberculosis (TB) patients related to a chain of recent TB transmissions were investigated. Mycobacterium tuberculosis (MTB) isolates (120) were genotyped using the restriction fragment length polymorphism-IS6110 (R), spacer oligotyping (S) and mycobacterial interspersed repetitive units-variable number of tandem repeats (M) methods. The MTB isolates were clustered and the clusters were grouped according to the similarities of their genotypes. Spearman’s rank correlation coefficients between the groups of MTB isolates with similar genotypes and those patient characteristics indicating a risk for a pulmonary TB (PTB) chain transmission were ana-lysed. The isolates showing similar genotypes were distributed as follows: SMR (5%), SM (12.5%), SR (1.67%), MR (0%), S (46.67%), M (5%) and R (0%). The remaining 35 cases were orphans. SMR exhibited a significant correlation (p < 0.05) with visits to clinics, municipalities and comorbidities (primarily diabetes mellitus). S correlated with drug consumption and M with comorbidities. SMR is needed to identify a social network in metropolitan areas for PTB transmission and S and M are able to detect risk factors as secondary components of a transmission chain of TB.

Original languageEnglish (US)
Pages (from-to)814-819
Number of pages6
JournalMemorias do Instituto Oswaldo Cruz
Volume109
Issue number6
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

Keywords

  • Genotyping
  • MTB
  • Mycobacterium tuberculosis
  • Population-based study
  • Risk factors
  • Tuberculosis transmission

ASJC Scopus subject areas

  • Microbiology (medical)

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