Correlations between SPECT regional cerebral blood flow and psychometric testing in patients with Alzheimer's disease

Marwan N. Sabbagh, Peggy Lynn, Satish Jhingran, Paul Massman, Javier Villanueva-Meyer, Jennifer Olup, Rachelle S. Doody

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Thirty-nine patients with probable Alzheimer's disease (AD) were studied with [99mTc]HMPAO SPECT and a standardized neuropsychological battery testing intellect, memory, attention, language, motor and praxis functions, and depression. Spearman rank correlations and multivariate regression analyses were performed to correlate quantitative regional perfusion deficits to these tests. Patients were found to have decreased perfusion of left frontal, parietal, and temporal regions relative to right. WAB repetition scores and bilateral temporal flow were significantly correlated (P < 0.01). Correlations between visual memory and bilateral temporal flow and those between Mini-Mental State/Geriatric Depression Scale scores and bihemispheric flow approached significance. Although in this study regional cerebral blood flow was relatively insensitive to neuroanatomical abnormalities underlying specific cognitive deficits, it may have some specificity for identifying the language disorder in AD.

Original languageEnglish (US)
Pages (from-to)68-74
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume9
Issue number1
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Regional Blood Flow
Single-Photon Emission-Computed Tomography
Psychometrics
Alzheimer Disease
Perfusion
Technetium Tc 99m Exametazime
Depression
Language Disorders
Parietal Lobe
Temporal Lobe
Geriatrics
Language
Multivariate Analysis
Regression Analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Correlations between SPECT regional cerebral blood flow and psychometric testing in patients with Alzheimer's disease. / Sabbagh, Marwan N.; Lynn, Peggy; Jhingran, Satish; Massman, Paul; Villanueva-Meyer, Javier; Olup, Jennifer; Doody, Rachelle S.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 9, No. 1, 01.01.1997, p. 68-74.

Research output: Contribution to journalArticle

Sabbagh, Marwan N. ; Lynn, Peggy ; Jhingran, Satish ; Massman, Paul ; Villanueva-Meyer, Javier ; Olup, Jennifer ; Doody, Rachelle S. / Correlations between SPECT regional cerebral blood flow and psychometric testing in patients with Alzheimer's disease. In: Journal of Neuropsychiatry and Clinical Neurosciences. 1997 ; Vol. 9, No. 1. pp. 68-74.
@article{ea7874aaecb44404a7bf8e27d7b1050b,
title = "Correlations between SPECT regional cerebral blood flow and psychometric testing in patients with Alzheimer's disease",
abstract = "Thirty-nine patients with probable Alzheimer's disease (AD) were studied with [99mTc]HMPAO SPECT and a standardized neuropsychological battery testing intellect, memory, attention, language, motor and praxis functions, and depression. Spearman rank correlations and multivariate regression analyses were performed to correlate quantitative regional perfusion deficits to these tests. Patients were found to have decreased perfusion of left frontal, parietal, and temporal regions relative to right. WAB repetition scores and bilateral temporal flow were significantly correlated (P < 0.01). Correlations between visual memory and bilateral temporal flow and those between Mini-Mental State/Geriatric Depression Scale scores and bihemispheric flow approached significance. Although in this study regional cerebral blood flow was relatively insensitive to neuroanatomical abnormalities underlying specific cognitive deficits, it may have some specificity for identifying the language disorder in AD.",
author = "Sabbagh, {Marwan N.} and Peggy Lynn and Satish Jhingran and Paul Massman and Javier Villanueva-Meyer and Jennifer Olup and Doody, {Rachelle S.}",
year = "1997",
month = "1",
day = "1",
doi = "10.1176/jnp.9.1.68",
language = "English (US)",
volume = "9",
pages = "68--74",
journal = "Journal of Neuropsychiatry and Clinical Neurosciences",
issn = "0895-0172",
publisher = "American Psychiatric Publishing Inc.",
number = "1",

}

TY - JOUR

T1 - Correlations between SPECT regional cerebral blood flow and psychometric testing in patients with Alzheimer's disease

AU - Sabbagh, Marwan N.

AU - Lynn, Peggy

AU - Jhingran, Satish

AU - Massman, Paul

AU - Villanueva-Meyer, Javier

AU - Olup, Jennifer

AU - Doody, Rachelle S.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Thirty-nine patients with probable Alzheimer's disease (AD) were studied with [99mTc]HMPAO SPECT and a standardized neuropsychological battery testing intellect, memory, attention, language, motor and praxis functions, and depression. Spearman rank correlations and multivariate regression analyses were performed to correlate quantitative regional perfusion deficits to these tests. Patients were found to have decreased perfusion of left frontal, parietal, and temporal regions relative to right. WAB repetition scores and bilateral temporal flow were significantly correlated (P < 0.01). Correlations between visual memory and bilateral temporal flow and those between Mini-Mental State/Geriatric Depression Scale scores and bihemispheric flow approached significance. Although in this study regional cerebral blood flow was relatively insensitive to neuroanatomical abnormalities underlying specific cognitive deficits, it may have some specificity for identifying the language disorder in AD.

AB - Thirty-nine patients with probable Alzheimer's disease (AD) were studied with [99mTc]HMPAO SPECT and a standardized neuropsychological battery testing intellect, memory, attention, language, motor and praxis functions, and depression. Spearman rank correlations and multivariate regression analyses were performed to correlate quantitative regional perfusion deficits to these tests. Patients were found to have decreased perfusion of left frontal, parietal, and temporal regions relative to right. WAB repetition scores and bilateral temporal flow were significantly correlated (P < 0.01). Correlations between visual memory and bilateral temporal flow and those between Mini-Mental State/Geriatric Depression Scale scores and bihemispheric flow approached significance. Although in this study regional cerebral blood flow was relatively insensitive to neuroanatomical abnormalities underlying specific cognitive deficits, it may have some specificity for identifying the language disorder in AD.

UR - http://www.scopus.com/inward/record.url?scp=0031037491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031037491&partnerID=8YFLogxK

U2 - 10.1176/jnp.9.1.68

DO - 10.1176/jnp.9.1.68

M3 - Article

VL - 9

SP - 68

EP - 74

JO - Journal of Neuropsychiatry and Clinical Neurosciences

JF - Journal of Neuropsychiatry and Clinical Neurosciences

SN - 0895-0172

IS - 1

ER -