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Corrigendum to “NF1 loss in estrogen receptor-positive breast cancer induces osteoclast formation and immunosuppression to promote bone metastasis” [Cancer Lett. 655 (2026) 218636]

  • Zifan Zhao
  • , Ze Yi Zheng
  • , Jonathan T. Lei
  • , Matthew J. Baik
  • , Yi Hsuan Wu
  • , Lauren K. Somes
  • , Andres F. Mosquera Paternina
  • , Omar A. Harb
  • , Owen A. Chang
  • , Fengshuo Liu
  • , Matthew V. Holt
  • , Junkai Wang
  • , Igor Bado
  • , Hai Wang
  • , George Miles
  • , Zbigniew Gugala
  • , Meenakshi Anurag
  • , Ahmed Elkhanany
  • , Yi Li
  • , Valentina Hoyos
  • Xiang H.F. Zhang, Eric C. Chang

Research output: Contribution to journalComment/debatepeer-review

Abstract

The authors regret that the supplementary figures appear without their corresponding figure legends. The online supplementary material should be updated to include the following supplementary figure legends: “Supplemental figure legends. Fig. S1. ER+ breast cancer cells influence bone remodeling in co-cultures. (A) Expression of MMP9 and MMP13 in MCF7 cells cultured in regular medium with full serum was measured by RNA-seq (CPM, count per million). (B) T47D and ZR75B cells were co-cultured with RAW264.7 cells as described in Fig. 3A. Quantification of TRAP+ cells at 0 and 1 ng/ml of RANKL is shown. (C) After MCF7-RAW264.7 co-culture, cells were cultured in serum-free medium for 2 days. The media were analyzed by mass-spectrometry after TCA precipitation. n = the number of independent experiments. P-values were calculated using the limma package in R (panel A and C) or paired t-tests (panel B). *P < 0.05. Fig. S2. NF1-depleted ER+ breast cancer cells more effectively suppress CD8+ T cell activity. (A) Proliferation and activation of CD4+ and CD8+ T cells in the presence of T47D cells were analyzed as in Fig. 6A. (B) Proliferation and activation of CD4+ T cells in the presence of MCF7 cells were analyzed as in Fig. 6A. P-values were calculated by paired t-tests. *P < 0.05. (C) Cell lysates from ER+ breast cancer cell lines were analyzed by western blotting. (D) MCF7, T47D and ZR75B cells were analyzed as in Fig. 6D. Representative flow cytometry plots are shown on the left, while apoptotic cancer cells were quantified on the right.” The authors also wish to update the RNA-seq data availability statement: the RNA-seq data generated in this study have been deposited in GEO under accession number GSE334772. In Section 2.5, “Mammary fat pad injection,” the reference to nude mice was included in error and should be removed. These corrections do not affect the scientific conclusions of the article. The authors would like to apologise for any inconvenience caused.

Original languageEnglish (US)
Article number218776
JournalCancer Letters
Volume658
DOIs
StateAccepted/In press - 2026

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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