Corticotropin-releasing activity of monokines

B. M R N J Woloski, E. M. Smith, Walter Meyer, G. M. Fuller, J. E. Blalock

Research output: Contribution to journalArticle

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Abstract

Hepatocyte-stimulating factor and interleukin-1 are proteins produced by monocytes in response to inflammatory challenge. Neither of these monokines had direct effects on steroid production by cultured adrenocortical cells. Both monokines stimulated pituitary cells (AtT-20) to release adrenocorticotropic hormone; interleukin-1 was equipotent with a combination of corticotropin- releasing factor and arginine vasopressin, and hepatocyte-stimulating factor was at least three times as effective. The synthetic glucocorticoid, dexamethasone, inhibited production of hepatocyte-stimulating factor by cultured monocytes. These results indicate an axis between monocytes and pituitary and adrenocortical cells which may play a role in regulating host defense.

Original languageEnglish (US)
Pages (from-to)1035-1037
Number of pages3
JournalScience
Volume230
Issue number4729
StatePublished - 1985

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Monokines
Adrenocorticotropic Hormone
Monocytes
Interleukin-6
Interleukin-1
Arginine Vasopressin
Corticotropin-Releasing Hormone
Dexamethasone
Glucocorticoids
Cultured Cells
Steroids
Proteins

ASJC Scopus subject areas

  • General

Cite this

Woloski, B. M. R. N. J., Smith, E. M., Meyer, W., Fuller, G. M., & Blalock, J. E. (1985). Corticotropin-releasing activity of monokines. Science, 230(4729), 1035-1037.

Corticotropin-releasing activity of monokines. / Woloski, B. M R N J; Smith, E. M.; Meyer, Walter; Fuller, G. M.; Blalock, J. E.

In: Science, Vol. 230, No. 4729, 1985, p. 1035-1037.

Research output: Contribution to journalArticle

Woloski, BMRNJ, Smith, EM, Meyer, W, Fuller, GM & Blalock, JE 1985, 'Corticotropin-releasing activity of monokines', Science, vol. 230, no. 4729, pp. 1035-1037.
Woloski BMRNJ, Smith EM, Meyer W, Fuller GM, Blalock JE. Corticotropin-releasing activity of monokines. Science. 1985;230(4729):1035-1037.
Woloski, B. M R N J ; Smith, E. M. ; Meyer, Walter ; Fuller, G. M. ; Blalock, J. E. / Corticotropin-releasing activity of monokines. In: Science. 1985 ; Vol. 230, No. 4729. pp. 1035-1037.
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