Corticotropin-releasing activity of monokines

B. M.R.N.J. Woloski, E. M. Smith, W. J. Meyer, G. M. Fuller, J. E. Blalock

Research output: Contribution to journalArticlepeer-review

418 Scopus citations


Hepatocyte-stimulating factor and interleukin-1 are proteins produced by monocytes in response to inflammatory challenge. Neither of these monokines had direct effects on steroid production by cultured adrenocortical cells. Both monokines stimulated pituitary cells (AtT-20) to release adrenocorticotropic hormone; interleukin-1 was equipotent with a combination of corticotropin- releasing factor and arginine vasopressin, and hepatocyte-stimulating factor was at least three times as effective. The synthetic glucocorticoid, dexamethasone, inhibited production of hepatocyte-stimulating factor by cultured monocytes. These results indicate an axis between monocytes and pituitary and adrenocortical cells which may play a role in regulating host defense.

Original languageEnglish (US)
Pages (from-to)1035-1037
Number of pages3
Issue number4729
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • General


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