Corticotropin-releasing activity of monokines

B. M.R.N.J. Woloski, E. M. Smith, W. J. Meyer, G. M. Fuller, J. E. Blalock

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Abstract

Hepatocyte-stimulating factor and interleukin-1 are proteins produced by monocytes in response to inflammatory challenge. Neither of these monokines had direct effects on steroid production by cultured adrenocortical cells. Both monokines stimulated pituitary cells (AtT-20) to release adrenocorticotropic hormone; interleukin-1 was equipotent with a combination of corticotropin- releasing factor and arginine vasopressin, and hepatocyte-stimulating factor was at least three times as effective. The synthetic glucocorticoid, dexamethasone, inhibited production of hepatocyte-stimulating factor by cultured monocytes. These results indicate an axis between monocytes and pituitary and adrenocortical cells which may play a role in regulating host defense.

Original languageEnglish (US)
Pages (from-to)1035-1037
Number of pages3
JournalScience
Volume230
Issue number4729
DOIs
StatePublished - Jan 1 1985

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Cite this

Woloski, B. M. R. N. J., Smith, E. M., Meyer, W. J., Fuller, G. M., & Blalock, J. E. (1985). Corticotropin-releasing activity of monokines. Science, 230(4729), 1035-1037. https://doi.org/10.1126/science.2997929