Cortisol stimulation by recombinant interferon-α2

Joe Roosth, Richard B. Pollard, S. Lori Brown, Walter Meyer

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-α2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-α2. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 × 106 units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
JournalJournal of Neuroimmunology
Volume12
Issue number4
DOIs
StatePublished - 1986

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Interferons
Hydrocortisone
Investigational Therapies
Intramuscular Injections
Radioimmunoassay
Clinical Trials
Serum
Neoplasms

Keywords

  • Cortisol stimulation
  • Interferon-α
  • recombinant
  • Serum
  • Tumor

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

Cortisol stimulation by recombinant interferon-α2 . / Roosth, Joe; Pollard, Richard B.; Brown, S. Lori; Meyer, Walter.

In: Journal of Neuroimmunology, Vol. 12, No. 4, 1986, p. 311-316.

Research output: Contribution to journalArticle

Roosth, J, Pollard, RB, Brown, SL & Meyer, W 1986, 'Cortisol stimulation by recombinant interferon-α2 ', Journal of Neuroimmunology, vol. 12, no. 4, pp. 311-316. https://doi.org/10.1016/0165-5728(86)90037-8
Roosth, Joe ; Pollard, Richard B. ; Brown, S. Lori ; Meyer, Walter. / Cortisol stimulation by recombinant interferon-α2 In: Journal of Neuroimmunology. 1986 ; Vol. 12, No. 4. pp. 311-316.
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