Craniofacial hyperhidrosis successfully treated with topical glycopyrrolate

Join Y. Luh, Thomas A. Blackwell

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Treatment of craniofacial hyperhidrosis currently consists of thoracic sympathectomy, which is not widely available. Oral anticholinergic agents and β-blockers may be effective but also carry significant side effects. We describe a healthy, active 27-year-old male resident physician who had excessive facial sweating with minimal exertion or stress. The sweating was especially pronounced on the forehead, nose, and upper lip. Daily topical application of a 0.5% glycopyrrolate solution to the face and forehead was offered. After the first treatment, facial sweating was significantly reduced and was well controlled under stressful situations, without any discomfort to the skin. No loss of efficacy was seen after multiple face washings. Facial hyperhidrosis recurred after withdrawal of the glycopyrrolate for 2 days, confirming its therapeutic effect. Two years later, he continues to use glycopyrrolate as needed. We conclude that topical glycopyrrolate is effective in treating craniofacial hyperhidrosis and is associated with few adverse effects.

Original languageEnglish (US)
Pages (from-to)756-758
Number of pages3
JournalSouthern Medical Journal
Volume95
Issue number7
StatePublished - 2002

Fingerprint

Glycopyrrolate
Hyperhidrosis
Sweating
Forehead
Sympathectomy
Cholinergic Antagonists
Therapeutic Uses
Lip
Nose
Thorax
Physicians
Skin
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Craniofacial hyperhidrosis successfully treated with topical glycopyrrolate. / Luh, Join Y.; Blackwell, Thomas A.

In: Southern Medical Journal, Vol. 95, No. 7, 2002, p. 756-758.

Research output: Contribution to journalArticle

Luh, Join Y. ; Blackwell, Thomas A. / Craniofacial hyperhidrosis successfully treated with topical glycopyrrolate. In: Southern Medical Journal. 2002 ; Vol. 95, No. 7. pp. 756-758.
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