CREB modulates excitability of nucleus accumbens neurons

Yan Dong, Thomas Green, Daniel Saal, Helene Marie, Rachael Neve, Eric J. Nestler, Robert C. Malenka

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc). Expression of active CREB in rat NAc medium spiny neurons (MSNs) increased their excitability, whereas dominant-negative CREB had the opposite effect. Decreasing excitability of NAc MSNs in vivo by overexpression of potassium channels enhanced locomotor responses to cocaine, suggesting that the increased NAc MSN excitability caused by CREB helped to limit behavioral sensitivity to cocaine.

Original languageEnglish (US)
Pages (from-to)475-477
Number of pages3
JournalNature Neuroscience
Volume9
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

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Cyclic AMP Response Element-Binding Protein
Nucleus Accumbens
Neurons
Cocaine
Potassium Channels
Street Drugs

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dong, Y., Green, T., Saal, D., Marie, H., Neve, R., Nestler, E. J., & Malenka, R. C. (2006). CREB modulates excitability of nucleus accumbens neurons. Nature Neuroscience, 9(4), 475-477. https://doi.org/10.1038/nn1661

CREB modulates excitability of nucleus accumbens neurons. / Dong, Yan; Green, Thomas; Saal, Daniel; Marie, Helene; Neve, Rachael; Nestler, Eric J.; Malenka, Robert C.

In: Nature Neuroscience, Vol. 9, No. 4, 04.2006, p. 475-477.

Research output: Contribution to journalArticle

Dong, Y, Green, T, Saal, D, Marie, H, Neve, R, Nestler, EJ & Malenka, RC 2006, 'CREB modulates excitability of nucleus accumbens neurons', Nature Neuroscience, vol. 9, no. 4, pp. 475-477. https://doi.org/10.1038/nn1661
Dong Y, Green T, Saal D, Marie H, Neve R, Nestler EJ et al. CREB modulates excitability of nucleus accumbens neurons. Nature Neuroscience. 2006 Apr;9(4):475-477. https://doi.org/10.1038/nn1661
Dong, Yan ; Green, Thomas ; Saal, Daniel ; Marie, Helene ; Neve, Rachael ; Nestler, Eric J. ; Malenka, Robert C. / CREB modulates excitability of nucleus accumbens neurons. In: Nature Neuroscience. 2006 ; Vol. 9, No. 4. pp. 475-477.
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