CREB modulates excitability of nucleus accumbens neurons

Yan Dong, Thomas Green, Daniel Saal, Helene Marie, Rachael Neve, Eric J. Nestler, Robert C. Malenka

Research output: Contribution to journalArticlepeer-review

275 Scopus citations


Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc). Expression of active CREB in rat NAc medium spiny neurons (MSNs) increased their excitability, whereas dominant-negative CREB had the opposite effect. Decreasing excitability of NAc MSNs in vivo by overexpression of potassium channels enhanced locomotor responses to cocaine, suggesting that the increased NAc MSN excitability caused by CREB helped to limit behavioral sensitivity to cocaine.

Original languageEnglish (US)
Pages (from-to)475-477
Number of pages3
JournalNature Neuroscience
Issue number4
StatePublished - Apr 2006
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


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