CREB modulates excitability of nucleus accumbens neurons

Yan Dong, Thomas Green, Daniel Saal, Helene Marie, Rachael Neve, Eric J. Nestler, Robert C. Malenka

Research output: Contribution to journalArticle

232 Scopus citations

Abstract

Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc). Expression of active CREB in rat NAc medium spiny neurons (MSNs) increased their excitability, whereas dominant-negative CREB had the opposite effect. Decreasing excitability of NAc MSNs in vivo by overexpression of potassium channels enhanced locomotor responses to cocaine, suggesting that the increased NAc MSN excitability caused by CREB helped to limit behavioral sensitivity to cocaine.

Original languageEnglish (US)
Pages (from-to)475-477
Number of pages3
JournalNature Neuroscience
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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    Dong, Y., Green, T., Saal, D., Marie, H., Neve, R., Nestler, E. J., & Malenka, R. C. (2006). CREB modulates excitability of nucleus accumbens neurons. Nature Neuroscience, 9(4), 475-477. https://doi.org/10.1038/nn1661