Crimean-Congo hemorrhagic fever in Turkey

S. Sami Karti; Zekaver Odabasi; Volkan Korten; Mustafa Yilmaz; Mehmet Sonmez; Rahmet Caylan; Elif Akdogan; Necmi Eren; Iftihar Koksai; Ercument Ovali; Bobbie R. Erickson; Martin J. Vincent; Stuart T. Nichol; James A. Comer; Pierre E. Rollin; Thomas G. Ksiazek

doi:10.3201/eid1008.030928

Crimean-Congo hemorrhagic fever in Turkey

S. Sami Karti, Zekaver Odabasi, Volkan Korten, Mustafa Yilmaz, Mehmet Sonmez, Rahmet Caylan, Elif Akdogan, Necmi Eren, Iftihar Koksai, Ercument Ovali, Bobbie R. Erickson, Martin J. Vincent, Stuart T. Nichol, James A. Comer, Pierre E. Rollin, Thomas G. Ksiazek

Research output: Contribution to journal › Article › peer-review

271 Scopus citations

Abstract

In 2002 and 2003, a total of 19 persons in Turkey had suspected cases of Crimean-Congo hemorrhagic fever (CCHF) or a similar viral infection. Six serum samples were tested; all six were found positive for immunoglobulin M antibodies against CCHF virus. Two of the samples yielded CCHF virus isolates. Genetic analysis of the virus isolates showed them to be closely related to isolates from former Yugoslavia and southwestern Russia. These cases are the first of CCHF reported from Turkey. Eighteen patients handled livestock, and one was a nurse with probable nosocomial infection. The case-fatality rate was 20% among confirmed CCHF case-patients (1 of 5 patients), and the overall case-patient fatality rate was 11% (2 of 19 patients). In addition to previously reported symptoms and signs, we report hemophagocytosis in 50% of our patients, which is the first report of this clinical phenomenon associated with CCHF.

Original language	English (US)
Pages (from-to)	1379-1384
Number of pages	6
Journal	Emerging infectious diseases
Volume	10
Issue number	8
DOIs	https://doi.org/10.3201/eid1008.030928
State	Published - Aug 2004
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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@article{ed615022eff54a16a354748437d140ab,

title = "Crimean-Congo hemorrhagic fever in Turkey",

abstract = "In 2002 and 2003, a total of 19 persons in Turkey had suspected cases of Crimean-Congo hemorrhagic fever (CCHF) or a similar viral infection. Six serum samples were tested; all six were found positive for immunoglobulin M antibodies against CCHF virus. Two of the samples yielded CCHF virus isolates. Genetic analysis of the virus isolates showed them to be closely related to isolates from former Yugoslavia and southwestern Russia. These cases are the first of CCHF reported from Turkey. Eighteen patients handled livestock, and one was a nurse with probable nosocomial infection. The case-fatality rate was 20% among confirmed CCHF case-patients (1 of 5 patients), and the overall case-patient fatality rate was 11% (2 of 19 patients). In addition to previously reported symptoms and signs, we report hemophagocytosis in 50% of our patients, which is the first report of this clinical phenomenon associated with CCHF.",

author = "Karti, {S. Sami} and Zekaver Odabasi and Volkan Korten and Mustafa Yilmaz and Mehmet Sonmez and Rahmet Caylan and Elif Akdogan and Necmi Eren and Iftihar Koksai and Ercument Ovali and Erickson, {Bobbie R.} and Vincent, {Martin J.} and Nichol, {Stuart T.} and Comer, {James A.} and Rollin, {Pierre E.} and Ksiazek, {Thomas G.}",

year = "2004",

month = aug,

doi = "10.3201/eid1008.030928",

language = "English (US)",

volume = "10",

pages = "1379--1384",

journal = "Emerging infectious diseases",

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AU - Karti, S. Sami

AU - Odabasi, Zekaver

AU - Korten, Volkan

AU - Yilmaz, Mustafa

AU - Sonmez, Mehmet

AU - Caylan, Rahmet

AU - Akdogan, Elif

AU - Eren, Necmi

AU - Koksai, Iftihar

AU - Ovali, Ercument

AU - Erickson, Bobbie R.

AU - Vincent, Martin J.

AU - Nichol, Stuart T.

AU - Comer, James A.

AU - Rollin, Pierre E.

AU - Ksiazek, Thomas G.

PY - 2004/8

Y1 - 2004/8

N2 - In 2002 and 2003, a total of 19 persons in Turkey had suspected cases of Crimean-Congo hemorrhagic fever (CCHF) or a similar viral infection. Six serum samples were tested; all six were found positive for immunoglobulin M antibodies against CCHF virus. Two of the samples yielded CCHF virus isolates. Genetic analysis of the virus isolates showed them to be closely related to isolates from former Yugoslavia and southwestern Russia. These cases are the first of CCHF reported from Turkey. Eighteen patients handled livestock, and one was a nurse with probable nosocomial infection. The case-fatality rate was 20% among confirmed CCHF case-patients (1 of 5 patients), and the overall case-patient fatality rate was 11% (2 of 19 patients). In addition to previously reported symptoms and signs, we report hemophagocytosis in 50% of our patients, which is the first report of this clinical phenomenon associated with CCHF.

AB - In 2002 and 2003, a total of 19 persons in Turkey had suspected cases of Crimean-Congo hemorrhagic fever (CCHF) or a similar viral infection. Six serum samples were tested; all six were found positive for immunoglobulin M antibodies against CCHF virus. Two of the samples yielded CCHF virus isolates. Genetic analysis of the virus isolates showed them to be closely related to isolates from former Yugoslavia and southwestern Russia. These cases are the first of CCHF reported from Turkey. Eighteen patients handled livestock, and one was a nurse with probable nosocomial infection. The case-fatality rate was 20% among confirmed CCHF case-patients (1 of 5 patients), and the overall case-patient fatality rate was 11% (2 of 19 patients). In addition to previously reported symptoms and signs, we report hemophagocytosis in 50% of our patients, which is the first report of this clinical phenomenon associated with CCHF.

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Crimean-Congo hemorrhagic fever in Turkey

Abstract

ASJC Scopus subject areas

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