Crimean-Congo hemorrhagic fever virus genomics and global diversity

Varough M. Deyde, Marina L. Khristova, Pierre E. Rollin, Thomas Ksiazek, Stuart T. Nichol

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

Crimean-Congo hemorrhagic fever (CCHF) is a severe illness with high case fatality that occurs in Africa, Europe, the Middle East, and Asia. The complete genomes of 13 geographically and temporally diverse virus strains were determined, and CCHF viruses were found to be highly variable with 20 and 8%, 31 and 27%, and 22 and 10% nucleotide and deduced amino acid differences detected among virus S (nucleocapsid), M (glycoprotein), and L (polymerase) genome segments, respectively. Distinct geographic lineages exist, but with multiple exceptions indicative of long-distance virus movement. Discrepancies among the virus S, M, and L phylogenetic tree topologies document multiple RNA segment reassortment events. An analysis of individual segment datasets suggests genetic recombination also occurs. For an arthropod-borne virus, the genomic plasticity of CCHF virus is surprisingly high.

Original languageEnglish (US)
Pages (from-to)8834-8842
Number of pages9
JournalJournal of Virology
Volume80
Issue number17
DOIs
StatePublished - Sep 2006
Externally publishedYes

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Crimean-Congo hemorrhagic fever virus
Genomics
Viruses
genomics
viruses
Crimean Hemorrhagic Fever
Genome
Congo
Arboviruses
genetic recombination
Nucleocapsid
nucleocapsid
arboviruses
Middle East
genome
Far East
topology
Genetic Recombination
glycoproteins
Glycoproteins

ASJC Scopus subject areas

  • Immunology

Cite this

Deyde, V. M., Khristova, M. L., Rollin, P. E., Ksiazek, T., & Nichol, S. T. (2006). Crimean-Congo hemorrhagic fever virus genomics and global diversity. Journal of Virology, 80(17), 8834-8842. https://doi.org/10.1128/JVI.00752-06

Crimean-Congo hemorrhagic fever virus genomics and global diversity. / Deyde, Varough M.; Khristova, Marina L.; Rollin, Pierre E.; Ksiazek, Thomas; Nichol, Stuart T.

In: Journal of Virology, Vol. 80, No. 17, 09.2006, p. 8834-8842.

Research output: Contribution to journalArticle

Deyde, VM, Khristova, ML, Rollin, PE, Ksiazek, T & Nichol, ST 2006, 'Crimean-Congo hemorrhagic fever virus genomics and global diversity', Journal of Virology, vol. 80, no. 17, pp. 8834-8842. https://doi.org/10.1128/JVI.00752-06
Deyde, Varough M. ; Khristova, Marina L. ; Rollin, Pierre E. ; Ksiazek, Thomas ; Nichol, Stuart T. / Crimean-Congo hemorrhagic fever virus genomics and global diversity. In: Journal of Virology. 2006 ; Vol. 80, No. 17. pp. 8834-8842.
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