Critical issues for engineering cord blood stem cells to produce insulin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/objectives: The objectives of using cord blood stem cells for treating type 1 diabetes are simple in principle yet complex in biological and molecular mechanisms. These are defined by the complexity of the insulin-producing unit of the pancreas, the islet. Islets are composed of various cell types that arise from diverse lineages and communicate by hormones, growth factors and small-molecule mediators. These processes are regulated by integration of signal transcluction pathways. While advances have been made to engineer umbilical cord blood stem cells to produce insulin, these studies only illuminate the potential of such cells to fulfil a necessary, but not sufficient, requirement for transplantation. Results/conclusions: The challenges ahead demand detailed understanding of molecular mechanisms to move from an opportunistic, phenotypic approach to transplantation and amelioration of blood glucose, to an orderly and logical approach to a biologically and medically meaningful solution. The issues include expansion to generate large numbers of cells, self-renewal to regulate the destiny of cord blood stem cells to repopulate the hematopoietic system, and multipotency of stem cells to generate the distinct cell types of an islet.

Original languageEnglish (US)
Pages (from-to)1251-1254
Number of pages4
JournalExpert Opinion on Biological Therapy
Volume8
Issue number9
DOIs
StatePublished - Sep 2008

Fingerprint

Stem cells
Fetal Blood
Blood Cells
Blood
Stem Cells
Insulin
Transplantation
Hematopoietic System
Hormones
Medical problems
Type 1 Diabetes Mellitus
Islets of Langerhans
Blood Glucose
Pancreas
Signal Transduction
Intercellular Signaling Peptides and Proteins
Engineers
Molecules

Keywords

  • Cord blood stem cell
  • Diabetes
  • Insulin

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry
  • Drug Discovery

Cite this

Critical issues for engineering cord blood stem cells to produce insulin. / Denner, Larry; Urban, Randall.

In: Expert Opinion on Biological Therapy, Vol. 8, No. 9, 09.2008, p. 1251-1254.

Research output: Contribution to journalArticle

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