Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

Huiling Cao; Ke Zhu; Lugui Qiu; Shuai Li; Hanjie Niu; Mu Hao; Shengyong Yang; Zhongfang Zhao; Yumei Lai; Judith L. Anderson; Jie Fan; Hee Jeong Im; Di Chen; G. David Roodman; Guozhi Xiao

doi:10.1074/jbc.M113.469973

Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

Huiling Cao
, Ke Zhu
, Lugui Qiu
, Shuai Li
, Hanjie Niu
, Mu Hao
, Shengyong Yang
, Zhongfang Zhao
, Yumei Lai
, Judith L. Anderson
, Jie Fan
, Hee Jeong Im
, Di Chen
, G. David Roodman
, Guozhi Xiao

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Background: Myeloma cells cause abnormal osteoclast formation and osteolysis. Results: Myeloma cells up-regulate AKT in osteoclast precursors and promote osteoclast formation. Systemic AKT inhibition blocks the myeloma-induced osteolysis and tumor growth in bone. Conclusion: AKT is critical for the myeloma promotion of osteoclast formation and osteolysis. Significance: AKT could be a useful target for treating patients with myeloma bone disease.

Original language	English (US)
Pages (from-to)	30399-30410
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	42
DOIs	https://doi.org/10.1074/jbc.M113.469973
State	Published - Oct 18 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M113.469973

Cite this

@article{69d62d94b99f487cbcd17d3aad4c2f91,

title = "Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis",

abstract = "Background: Myeloma cells cause abnormal osteoclast formation and osteolysis. Results: Myeloma cells up-regulate AKT in osteoclast precursors and promote osteoclast formation. Systemic AKT inhibition blocks the myeloma-induced osteolysis and tumor growth in bone. Conclusion: AKT is critical for the myeloma promotion of osteoclast formation and osteolysis. Significance: AKT could be a useful target for treating patients with myeloma bone disease.",

author = "Huiling Cao and Ke Zhu and Lugui Qiu and Shuai Li and Hanjie Niu and Mu Hao and Shengyong Yang and Zhongfang Zhao and Yumei Lai and Anderson, \{Judith L.\} and Jie Fan and Im, \{Hee Jeong\} and Di Chen and Roodman, \{G. David\} and Guozhi Xiao",

year = "2013",

month = oct,

day = "18",

doi = "10.1074/jbc.M113.469973",

language = "English (US)",

volume = "288",

pages = "30399--30410",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "42",

}

TY - JOUR

T1 - Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

AU - Cao, Huiling

AU - Zhu, Ke

AU - Qiu, Lugui

AU - Li, Shuai

AU - Niu, Hanjie

AU - Hao, Mu

AU - Yang, Shengyong

AU - Zhao, Zhongfang

AU - Lai, Yumei

AU - Anderson, Judith L.

AU - Fan, Jie

AU - Im, Hee Jeong

AU - Chen, Di

AU - Roodman, G. David

AU - Xiao, Guozhi

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Background: Myeloma cells cause abnormal osteoclast formation and osteolysis. Results: Myeloma cells up-regulate AKT in osteoclast precursors and promote osteoclast formation. Systemic AKT inhibition blocks the myeloma-induced osteolysis and tumor growth in bone. Conclusion: AKT is critical for the myeloma promotion of osteoclast formation and osteolysis. Significance: AKT could be a useful target for treating patients with myeloma bone disease.

AB - Background: Myeloma cells cause abnormal osteoclast formation and osteolysis. Results: Myeloma cells up-regulate AKT in osteoclast precursors and promote osteoclast formation. Systemic AKT inhibition blocks the myeloma-induced osteolysis and tumor growth in bone. Conclusion: AKT is critical for the myeloma promotion of osteoclast formation and osteolysis. Significance: AKT could be a useful target for treating patients with myeloma bone disease.

UR - https://www.scopus.com/pages/publications/84886878565

UR - https://www.scopus.com/pages/publications/84886878565#tab=citedBy

U2 - 10.1074/jbc.M113.469973

DO - 10.1074/jbc.M113.469973

M3 - Article

C2 - 24005670

AN - SCOPUS:84886878565

SN - 0021-9258

VL - 288

SP - 30399

EP - 30410

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 42

ER -

Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this