@article{800e374dcb494190821de112f3beb862,
title = "Cross-neutralization and viral fitness of SARS-CoV-2 Omicron sublineages",
abstract = "The rapid evolution of SARS-CoV-2 Omicron sublineages mandates a better understanding of viral replication and cross-neutralization among these sublineages. Here we used K18-hACE2 mice and primary human airway cultures to examine the viral fitness and antigenic relationship among Omicron sublineages. In both K18-hACE2 mice and human airway cultures, Omicron sublineages exhibited a replication order of BA.5 ≥ BA.2 ≥ BA.2.12.1 > BA.1; no difference in body weight loss was observed among different sublineage-infected mice. The BA.1-, BA.2-, BA.2.12.1-, and BA.5-infected mice developed distinguishable cross-neutralizations against Omicron sublineages, but exhibited little neutralization against the index virus (i.e. USA-WA1/2020) or the Delta variant. Surprisingly, the BA.5-infected mice developed higher neutralization activity against heterologous BA.2 and BA.2.12.1 than that against homologous BA.5; serum neutralizing titres did not always correlate with viral replication levels in infected animals. Our results revealed a distinct antigenic cartography of Omicron sublineages and support the bivalent vaccine approach.",
keywords = "SARS-CoV-2, antigenicity, neutralization, variants, viral fitness",
author = "Hongjie Xia and Jason Yeung and Birte Kalveram and Bills, {Cody J.} and Chen, {John Yun Chung} and Chaitanya Kurhade and Jing Zou and Widen, {Steven G.} and Mann, {Brian R.} and Rebecca Kondor and Davis, {C. Todd} and Bin Zhou and Wentworth, {David E.} and Xuping Xie and Shi, {Pei Yong}",
note = "Funding Information: We thank colleagues at the University of Texas Medical Branch (UTMB) for helpful discussions and Samuel S. Shepard and Reina Chau for their contributions in operationalizing ACMACS for high-throughput and portable usage. This research was partly funded by the Centers for Disease Control and Prevention. J.C. was supported by a T32 Biodefense Training Program Grant T32AI060549. P.Y.S. was supported by NIH contract HHSN272201600013C, and awards from the Sealy & Smith Foundation, the Kleberg Foundation, the John S. Dunn Foundation, the Amon G. Carter Foundation, the Summerfield Robert Foundation, and Edith and Robert Zinn. SSS is affiliated with the Centers for Disease Control and Prevention (CDC). RC is a CDC contractor with General Dynamics Information Technologies, Inc. Use of trade names is for identification only and does not imply endorsement by the US Centers for Disease Control and Prevention or the US Department of Health and Human Services. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention. Funding Information: This work was supported by Amon G. Carter Foundation; Centers for Disease Controls and Prevention (CDC); John S. Dunn Foundation; National Institutes of Health: [Grant Number HHSN272201600013C]; Edith and Robert Zinn; Summerfield G. Roberts Foundation; Sealy & Smith Foundation; Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation. We thank colleagues at the University of Texas Medical Branch (UTMB) for helpful discussions and Samuel S. Shepard and Reina Chau for their contributions in operationalizing ACMACS for high-throughput and portable usage. This research was partly funded by the Centers for Disease Control and Prevention. J.C. was supported by a T32 Biodefense Training Program Grant T32AI060549. P.Y.S. was supported by NIH contract HHSN272201600013C, and awards from the Sealy & Smith Foundation, the Kleberg Foundation, the John S. Dunn Foundation, the Amon G. Carter Foundation, the Summerfield Robert Foundation, and Edith and Robert Zinn. SSS is affiliated with the Centers for Disease Control and Prevention (CDC). RC is a CDC contractor with General Dynamics Information Technologies, Inc. Use of trade names is for identification only and does not imply endorsement by the US Centers for Disease Control and Prevention or the US Department of Health and Human Services. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention. Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",
year = "2023",
doi = "10.1080/22221751.2022.2161422",
language = "English (US)",
volume = "12",
journal = "Emerging Microbes and Infections",
issn = "2222-1751",
publisher = "Nature Publishing Group",
number = "1",
}