Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

Jing Zou; Chaitanya Kurhade; Hongjie Xia; Mingru Liu; Xuping Xie; Ping Ren; Pei-Yong Shi

doi:10.1038/s41467-022-30580-5

Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

Jing Zou, Chaitanya Kurhade, Hongjie Xia, Mingru Liu, Xuping Xie, Ping Ren, Pei-Yong Shi

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The Omicron SARS-CoV-2 has several distinct sublineages, among which sublineage BA.1 is responsible for the initial Omicron surge and is now being replaced by BA.2 worldwide, whereas BA.3 is currently at a low frequency. The ongoing BA.1-to-BA.2 replacement underscores the importance to understand the cross-neutralization among the three Omicron sublineages. Here we test the neutralization of BA.1-infected human sera against BA.2, BA.3, and USA/WA1-2020 (a strain isolated in late January 2020). The BA.1-infected sera neutralize BA.1, BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2s with geometric mean titers (GMTs) of 445, 107, 102, and 16, respectively. Thus, the neutralizing GMTs against heterologous BA.2, BA.3, and USA/WA1-2020 are 4.2-, 4.4-, and 28.4-fold lower than the GMT against homologous BA.1, respectively. These findings have implications in COVID-19 vaccine strategy.

Original language	English (US)
Article number	2956
Journal	Nature communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-30580-5
State	Published - Dec 2022

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

Access to Document

10.1038/s41467-022-30580-5

Cite this

@article{a0e16cfc94a84775896c403e7ea6d6a9,

title = "Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2",

abstract = "The Omicron SARS-CoV-2 has several distinct sublineages, among which sublineage BA.1 is responsible for the initial Omicron surge and is now being replaced by BA.2 worldwide, whereas BA.3 is currently at a low frequency. The ongoing BA.1-to-BA.2 replacement underscores the importance to understand the cross-neutralization among the three Omicron sublineages. Here we test the neutralization of BA.1-infected human sera against BA.2, BA.3, and USA/WA1-2020 (a strain isolated in late January 2020). The BA.1-infected sera neutralize BA.1, BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2s with geometric mean titers (GMTs) of 445, 107, 102, and 16, respectively. Thus, the neutralizing GMTs against heterologous BA.2, BA.3, and USA/WA1-2020 are 4.2-, 4.4-, and 28.4-fold lower than the GMT against homologous BA.1, respectively. These findings have implications in COVID-19 vaccine strategy.",

author = "Jing Zou and Chaitanya Kurhade and Hongjie Xia and Mingru Liu and Xuping Xie and Ping Ren and Pei-Yong Shi",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1038/s41467-022-30580-5",

language = "English (US)",

volume = "13",

journal = "Nature communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

AU - Zou, Jing

AU - Kurhade, Chaitanya

AU - Xia, Hongjie

AU - Liu, Mingru

AU - Xie, Xuping

AU - Ren, Ping

AU - Shi, Pei-Yong

PY - 2022/12

Y1 - 2022/12

N2 - The Omicron SARS-CoV-2 has several distinct sublineages, among which sublineage BA.1 is responsible for the initial Omicron surge and is now being replaced by BA.2 worldwide, whereas BA.3 is currently at a low frequency. The ongoing BA.1-to-BA.2 replacement underscores the importance to understand the cross-neutralization among the three Omicron sublineages. Here we test the neutralization of BA.1-infected human sera against BA.2, BA.3, and USA/WA1-2020 (a strain isolated in late January 2020). The BA.1-infected sera neutralize BA.1, BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2s with geometric mean titers (GMTs) of 445, 107, 102, and 16, respectively. Thus, the neutralizing GMTs against heterologous BA.2, BA.3, and USA/WA1-2020 are 4.2-, 4.4-, and 28.4-fold lower than the GMT against homologous BA.1, respectively. These findings have implications in COVID-19 vaccine strategy.

AB - The Omicron SARS-CoV-2 has several distinct sublineages, among which sublineage BA.1 is responsible for the initial Omicron surge and is now being replaced by BA.2 worldwide, whereas BA.3 is currently at a low frequency. The ongoing BA.1-to-BA.2 replacement underscores the importance to understand the cross-neutralization among the three Omicron sublineages. Here we test the neutralization of BA.1-infected human sera against BA.2, BA.3, and USA/WA1-2020 (a strain isolated in late January 2020). The BA.1-infected sera neutralize BA.1, BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2s with geometric mean titers (GMTs) of 445, 107, 102, and 16, respectively. Thus, the neutralizing GMTs against heterologous BA.2, BA.3, and USA/WA1-2020 are 4.2-, 4.4-, and 28.4-fold lower than the GMT against homologous BA.1, respectively. These findings have implications in COVID-19 vaccine strategy.

UR - http://www.scopus.com/inward/record.url?scp=85130689990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85130689990&partnerID=8YFLogxK

U2 - 10.1038/s41467-022-30580-5

DO - 10.1038/s41467-022-30580-5

M3 - Article

C2 - 35618703

AN - SCOPUS:85130689990

SN - 2041-1723

VL - 13

JO - Nature communications

JF - Nature communications

IS - 1

M1 - 2956

ER -

Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this