Cross-reaction of two different somatostatin antisera with calcitonin gene-related peptide

J. Ishizuka, C. Yanaihara, N. Yanaihara, G. H. Greeley, C. W. Cooper, J. C. Thompson

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Abstract

Two different anti-somatostatin antisera, R-101 and OAL-273, cross-react with rat calcitonin gene-related peptide (1-37) (CGRP). CGRP amounts, in excess of 6.25 x 10-9 M, cross-react with R-101 in the somatostatin radioimmunoassay. CGRP amounts, in excess of 1.6 x 10-9 M, cross-react with OAL-273. Both CGRP displacement curves are parallel to that of synthetic somatostatin (1-14). Comparison of ID50's shows that the cross-reactivity of CGRP with R-101 and OAL-273 are 0.02 and 0.1% of somatostatin, respectively.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume189
Issue number1
StatePublished - 1988

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ishizuka, J., Yanaihara, C., Yanaihara, N., Greeley, G. H., Cooper, C. W., & Thompson, J. C. (1988). Cross-reaction of two different somatostatin antisera with calcitonin gene-related peptide. Proceedings of the Society for Experimental Biology and Medicine, 189(1), 1-4.