Cross-Reaction of Two Different Somatostatin Antisera with Calcitonin Gene-Related Peptide

Jin Ishizuka, George H. Greeley, James C. Thompson, Chizuko Yanaihara, Noboru Yanaihara, Cary W. Cooper

    Research output: Contribution to journalArticle

    9 Scopus citations

    Abstract

    Two different anti-somatostatin antisera, R-101 and OAL-273, cross-react with rat calcitonin gene-related peptide (1–37) (CGRP). CGRP amounts, in excess of 6.25 × 10-9M, cross-react with R-101 in the somatostatin radioimmunoassay. CGRP amounts, in excess of 1.6 × 10-9M, cross-react with OAL-273. Both CGRP displacement curves are parallel to that of synthetic somatostatin (1–14). Comparison of ID50's shows that the cross-reactivity of CGRP with R-101 and OAL-273 are 0.02 and 0.1% of somatostatin, respectively.

    Original languageEnglish (US)
    Pages (from-to)1-4
    Number of pages4
    JournalProceedings of the Society for Experimental Biology and Medicine
    Volume189
    Issue number1
    DOIs
    StatePublished - Oct 1988

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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