Cryptosporidiosis in Houston, Texas: A report of 95 cases

Rayhan Hashmey, Nathaniel H. Smith, Stanley Cron, Edward A. Graviss, Cynthia L. Chappell, A. Clinton White

Research output: Contribution to journalArticle

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Abstract

Cryptosporidiosis is an important cause of diarrhea. We identified 95 patients with cryptosporidiosis over a 6-year period in our county hospital system, including 9 children and 86 adults infected with the human immunodeficiency virus (HIV). Risk factors included male-to-male sexual practices and Hispanic race. Diarrhea, weight loss, and gastrointestinal complaints were the most common symptoms at presentation. Among the HIV- infected adults, 20 (23%) developed biliary tract disease. Biliary involvement was associated with low CD4 counts. Treatment with paromomycin and antimotility agents was effective in reducing diarrheal symptoms in 54 of 70 (77%) patients with the acquired immunodeficiency syndrome (AIDS), although there was a high rate of relapse. Paromomycin did not prevent the development of biliary disease. Biliary disease responded to cholecystectomy or sphincterotomy with stent placement. Though often a cause of morbidity, cryptosporidiosis was only rarely the cause of death, even among patients with HIV. Cryptosporidiosis continues to be an important medical problem even in developed countries. Current methods of prevention and treatment are suboptimal.

Original languageEnglish (US)
Pages (from-to)118-139
Number of pages22
JournalMedicine
Volume76
Issue number2
DOIs
StatePublished - Mar 1997
Externally publishedYes

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Cryptosporidiosis
Paromomycin
HIV
Diarrhea
Biliary Tract Diseases
County Hospitals
Cholecystectomy
CD4 Lymphocyte Count
Hispanic Americans
Developed Countries
Stents
Weight Loss
Cause of Death
Acquired Immunodeficiency Syndrome
Morbidity
Recurrence
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hashmey, R., Smith, N. H., Cron, S., Graviss, E. A., Chappell, C. L., & White, A. C. (1997). Cryptosporidiosis in Houston, Texas: A report of 95 cases. Medicine, 76(2), 118-139. https://doi.org/10.1097/00005792-199703000-00004

Cryptosporidiosis in Houston, Texas : A report of 95 cases. / Hashmey, Rayhan; Smith, Nathaniel H.; Cron, Stanley; Graviss, Edward A.; Chappell, Cynthia L.; White, A. Clinton.

In: Medicine, Vol. 76, No. 2, 03.1997, p. 118-139.

Research output: Contribution to journalArticle

Hashmey, R, Smith, NH, Cron, S, Graviss, EA, Chappell, CL & White, AC 1997, 'Cryptosporidiosis in Houston, Texas: A report of 95 cases', Medicine, vol. 76, no. 2, pp. 118-139. https://doi.org/10.1097/00005792-199703000-00004
Hashmey R, Smith NH, Cron S, Graviss EA, Chappell CL, White AC. Cryptosporidiosis in Houston, Texas: A report of 95 cases. Medicine. 1997 Mar;76(2):118-139. https://doi.org/10.1097/00005792-199703000-00004
Hashmey, Rayhan ; Smith, Nathaniel H. ; Cron, Stanley ; Graviss, Edward A. ; Chappell, Cynthia L. ; White, A. Clinton. / Cryptosporidiosis in Houston, Texas : A report of 95 cases. In: Medicine. 1997 ; Vol. 76, No. 2. pp. 118-139.
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