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Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain
Natalia Mast
,
Mark Andrew White
, Ingemar Bjorkhem
, Eric F. Johnson
, C. David Stout
, Irina A. Pikuleva
Biochemistry & Molecular Biology
Research output
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Article
›
peer-review
116
Scopus citations
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Dive into the research topics of 'Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain'. Together they form a unique fingerprint.
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Keyphrases
Hydroxylase
100%
Cytochrome P450 (CYP450)
100%
Cholesterol
100%
Substrate-free
100%
Therapeutic Agents
20%
In Vitro Assay
10%
Recombinant
10%
Active Sites
10%
Xenobiotics
10%
Conformational Change
10%
High Affinity
10%
Structural Information
10%
Oxygenation
10%
Helix
10%
Coactivator
10%
Major Pathway
10%
Biochemical Data
10%
Enzyme Active Site
10%
24S-hydroxycholesterol
10%
Cholesterol Removal
10%
Substrate-induced
10%
Two-crystal
10%
Free-form Structures
10%
Second-order Structure
10%
Banana-shaped
10%
C-loop
10%
Biochemistry, Genetics and Molecular Biology
Crystal Structure
100%
Oxygenase
100%
Cytochrome P450
100%
Sulfate
20%
Active Site
10%
Conformational Change
10%
Enzyme Active Site
10%
Oxygenation
10%