TY - JOUR
T1 - Culture-negative liver abscess identified with plasma microbial cell-free DNA sequencing
T2 - A case report
AU - Xue, Yuanchao
AU - Cerqueira, Filipe M.
AU - Stevenson, Heather L.
AU - Williams-Bouyer, Natalie
AU - Fang, Rong
N1 - Publisher Copyright:
© 2025 The Author(s)
PY - 2025/6
Y1 - 2025/6
N2 - Pyogenic liver abscess (PLA) is a potentially life-threatening disease. Early diagnosis and appropriate treatment are crucial to ensure high-quality healthcare for patients with PLA. However, this is complicated by their non-specific clinical symptoms. In addition, the etiologic organisms responsible for PLA are frequently culture-negative, thus complicating clinical decision-making. Here, we report a case of PLA caused by Streptococcus intermedius, as identified via DNA metagenomic sequencing of plasma.
AB - Pyogenic liver abscess (PLA) is a potentially life-threatening disease. Early diagnosis and appropriate treatment are crucial to ensure high-quality healthcare for patients with PLA. However, this is complicated by their non-specific clinical symptoms. In addition, the etiologic organisms responsible for PLA are frequently culture-negative, thus complicating clinical decision-making. Here, we report a case of PLA caused by Streptococcus intermedius, as identified via DNA metagenomic sequencing of plasma.
KW - Next-generation sequencing
KW - Pyogenic liver abscess
KW - Streptococcus anginosus group
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U2 - 10.1016/j.imj.2025.100180
DO - 10.1016/j.imj.2025.100180
M3 - Article
C2 - 40491516
AN - SCOPUS:105005447517
SN - 2097-0684
VL - 4
JO - Infectious Medicine
JF - Infectious Medicine
IS - 2
M1 - 100180
ER -