Curcumin as scaffold for drug discovery against neurodegenerative diseases

Filippa Lo Cascio, Paola Marzullo, Rakez Kayed, Antonio Palumbo Piccionello

Research output: Contribution to journalReview articlepeer-review

Abstract

Neurodegenerative diseases (NDs) are one of major public health problems and their impact is continuously growing. Curcumin has been proposed for the treatment of several of these pathologies, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) due to the ability of this molecule to reduce inflammation and aggregation of involved proteins. Nevertheless, the poor metabolic stability and bioavailability of curcumin reduce the possibilities of its practical use. For these reasons, many curcumin derivatives were synthetized in order to overcome some limitations. In this review will be highlighted recent results on modification of curcumin scaffold in the search of new effective therapeutic agents against NDs, with particular emphasis on AD.

Original languageEnglish (US)
Article number173
Pages (from-to)1-25
Number of pages25
JournalBiomedicines
Volume9
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • Alzheimer’s disease
  • Amyloid
  • Curcumin
  • Tau

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

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