Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling

Sara M. Johnson, Pat Gulhati, Isela Arrieta, Xiaofu Wang, Tatsuo Uchida, Tianyan Gao, B. Mark Evers

Research output: Contribution to journalArticle

107 Scopus citations

Abstract

Background: Curcumin, a natural polyphenol product of the plant Curcuma longa, has been shown to inhibit the growth and progression of colorectal cancer; however, the anticancer mechanism of curcumin remains to be elucidated. Materials and Methods: Colorectal cancer cells were treated with curcumin and changes in proliferation, protein and mRNA levels were analyzed. Results: Curcumin inhibited proliferation of colorectal cancer cells. This effect was mediated by inhibition of mammalian target of rapamycin (mTOR) signaling as evidenced by decreased phosphorylation of downstream effectors of mTOR complex 1 (mTORC1), p70S6K and 4E-BP1. Curcumin decreased total expression of mTOR, Raptor and Rictor protein and mRNA levels. Surprisingly, curcumin induced phosphorylation of Akt(Ser 473); this effect may be attributed to a decrease in levels of the PHLPP1 phosphatase, an inhibitor of Akt. Conclusion: Our data suggest that curcumin, a natural compound, may exert its antiproliferative effects by inhibition of mTOR signaling and thus may represent a novel class of mTOR inhibitor.

Original languageEnglish (US)
Pages (from-to)3185-3190
Number of pages6
JournalAnticancer Research
Volume29
Issue number8
StatePublished - Aug 1 2009

Keywords

  • Akt
  • Colorectal cancer
  • Curcumin
  • mTOR
  • PHLPP
  • Raptor
  • Rictor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Johnson, S. M., Gulhati, P., Arrieta, I., Wang, X., Uchida, T., Gao, T., & Evers, B. M. (2009). Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. Anticancer Research, 29(8), 3185-3190.