Current management of gastrointestinal carcinoid tumors

Kenneth J. Woodside, Courtney Townsend, B. Mark Evers

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Gastrointestinal carcinoid tumors are rare neuroendocrine tumors arising from the embryologic primitive gut. Depending on the location in the gastrointestinal tract, these tumors may secrete a variety of hormonally active substances. However, many of these tumors are found incidentally, or the diagnosis is made postoperatively. Also, there is a significant incidence of multicentric carcinoid tumors and synchronous noncarcinoid malignancies in these patients. Treatment is usually based on the size of the tumor. Surgical resection remains the cornerstone of therapy. For advanced metastatic disease, somatostatin analog therapy and surgical debulking provide the best symptomatic relief and may improve survival. Recent studies have demonstrated a benefit from radiolabeled somatostatin analogs for carcinoid tumor localization. In contrast, radiolabeled somatostatin analogs have shown little therapeutic benefit. Future directions include somatostatin receptor profiling of carcinoid tumors, with somatostatin analog therapy targeting the specific receptors.

Original languageEnglish (US)
Pages (from-to)742-756
Number of pages15
JournalJournal of Gastrointestinal Surgery
Volume8
Issue number6
DOIs
StatePublished - Sep 10 2004

Fingerprint

Carcinoid Tumor
Somatostatin
Neoplasms
Therapeutics
Gastrula
Somatostatin Receptors
Neuroendocrine Tumors
Gastrointestinal Tract
Survival
Incidence

Keywords

  • carcinoid syndrome
  • Carcinoid tumor
  • gastrointestinal tract
  • neuroendocrine tumor
  • review
  • somatostatin

ASJC Scopus subject areas

  • Surgery

Cite this

Current management of gastrointestinal carcinoid tumors. / Woodside, Kenneth J.; Townsend, Courtney; Mark Evers, B.

In: Journal of Gastrointestinal Surgery, Vol. 8, No. 6, 10.09.2004, p. 742-756.

Research output: Contribution to journalArticle

Woodside, Kenneth J. ; Townsend, Courtney ; Mark Evers, B. / Current management of gastrointestinal carcinoid tumors. In: Journal of Gastrointestinal Surgery. 2004 ; Vol. 8, No. 6. pp. 742-756.
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