Current review of in vivo GBM rodent models: Emphasis on the CNS-1 tumour model

Valerie L. Jacobs, Pablo A. Valdes, William F. Hickey, Joyce A. de Leo

Research output: Contribution to journalReview articlepeer-review

167 Scopus citations

Abstract

GBM (glioblastoma multiforme) is a highly aggressive brain tumour with very poor prognosis despite multi-modalities of treatment. Furthermore, recent failure of targeted therapy for these tumours highlights the need of appropriate rodent models for preclinical studies. In this review, we highlight the most commonly used rodent models (U251, U86, GL261, C6, 9L and CNS-1) with a focus on the pathological and genetic similarities to the human disease. We end with a comprehensive review of the CNS-1 rodent model.

Original languageEnglish (US)
Article numbere00063
Pages (from-to)171-181
Number of pages11
JournalASN Neuro
Volume3
Issue number3
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • 9L
  • C6
  • CNS-1
  • GL261
  • U251
  • U87

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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