Abstract
Severe Fever with Thrombocytopenia Syndrome (SFTS) is a new emerging tick-borne disease caused by the phlebovirus, SFTS virus (SFTSV). The virus was discovered in central China in 2009 and has since been identified in both Japan and South Korea. Significant progress has been made on the molecular biology of the virus, and this has been used to develop diagnostic assays and reagents. Less progress has been made on the epidemiology, maintenance and transmission, clinical manifestations, immunological responses, and treatment regimens. A number of animal models have been investigated but, to date, none recapitulate all the clinical manifestations seen in humans. Vaccine development is at an early discovery phase.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 72-78 |
| Number of pages | 7 |
| Journal | Current Opinion in Virology |
| Volume | 29 |
| DOIs | |
| State | Published - Apr 1 2018 |
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ASJC Scopus subject areas
- Virology
Cite this
Current status of Severe Fever with Thrombocytopenia Syndrome vaccine development. / Reece, Lisa M.; Beasley, David; Milligan, Gregg; Sarathy, Vanessa; Barrett, Alan.
In: Current Opinion in Virology, Vol. 29, 01.04.2018, p. 72-78.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Current status of Severe Fever with Thrombocytopenia Syndrome vaccine development
AU - Reece, Lisa M.
AU - Beasley, David
AU - Milligan, Gregg
AU - Sarathy, Vanessa
AU - Barrett, Alan
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Severe Fever with Thrombocytopenia Syndrome (SFTS) is a new emerging tick-borne disease caused by the phlebovirus, SFTS virus (SFTSV). The virus was discovered in central China in 2009 and has since been identified in both Japan and South Korea. Significant progress has been made on the molecular biology of the virus, and this has been used to develop diagnostic assays and reagents. Less progress has been made on the epidemiology, maintenance and transmission, clinical manifestations, immunological responses, and treatment regimens. A number of animal models have been investigated but, to date, none recapitulate all the clinical manifestations seen in humans. Vaccine development is at an early discovery phase.
AB - Severe Fever with Thrombocytopenia Syndrome (SFTS) is a new emerging tick-borne disease caused by the phlebovirus, SFTS virus (SFTSV). The virus was discovered in central China in 2009 and has since been identified in both Japan and South Korea. Significant progress has been made on the molecular biology of the virus, and this has been used to develop diagnostic assays and reagents. Less progress has been made on the epidemiology, maintenance and transmission, clinical manifestations, immunological responses, and treatment regimens. A number of animal models have been investigated but, to date, none recapitulate all the clinical manifestations seen in humans. Vaccine development is at an early discovery phase.
UR - http://www.scopus.com/inward/record.url?scp=85049379178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049379178&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2018.03.005
DO - 10.1016/j.coviro.2018.03.005
M3 - Review article
VL - 29
SP - 72
EP - 78
JO - Current Opinion in Virology
JF - Current Opinion in Virology
SN - 1879-6257
ER -