Current therapies in treatment and prevention of fracture wound biofilms: Why a multifaceted approach is essential for resolving persistent infections

Krystle A. Blanchette, Joseph C. Wenke

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Traumatic orthopedic injuries, particularly extremity wounds, are a significant cause of morbidity. Despite prophylactic antibiotic treatment and surgical intervention, persistent infectious complications can and do occur. Persistent bacterial infections are often caused by biofilms, communities of antibiotic tolerant bacteria encased within a matrix. The structural and metabolic differences in this mode of growth make treatment difficult. Herein, we describe both established and novel, experimental treatments targeted at various stages of wound healing that are specifically aimed at reducing and eliminating biofilm bacteria. Importantly, the highly tolerant nature of these bacterial communities suggests that most singular approaches could be circumvented and a multifaceted, combinatorial approach will be the most effective strategy for treating these complicated infections.

Original languageEnglish (US)
Pages (from-to)50-67
Number of pages18
JournalJournal of Bone and Joint Infection
Volume3
Issue number2
DOIs
StatePublished - Apr 12 2018
Externally publishedYes

Keywords

  • Antimicrobial treatment
  • Biofilm
  • Chronic infection
  • Persistent infection
  • Wound care

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery
  • Infectious Diseases

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