Current use and development of vaccines for Japanese encephalitis

David W.C. Beasley, Penny Lewthwaite, Tom Solomon

Research output: Contribution to journalReview article

70 Scopus citations

Abstract

Background: Japanese encephalitis (JE) is a significant cause of human morbidity and mortality throughout Asia. Vaccines for JE have been available for many years and their use has been effective in reducing the incidence of A disease in several countries but, as disease incidence has decreased, concerns regarding adverse events following immunisation have increased. Objective: To review existing JE vaccines and new candidates in advanced preclinical or clinical evaluation. Methods: The review primarily covers published and some unpublished literature from the past decade describing current use of approved A vaccines in various parts of the world, and advanced development and clinical testing of alternative vaccine candidates. Results/conclusion: There is a clear need for additional licensing of existing or new A vaccines. Several promising candidates are currently in use or completing clinical trials.

Original languageEnglish (US)
Pages (from-to)95-106
Number of pages12
JournalExpert Opinion on Biological Therapy
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2008

Keywords

  • Chimeric
  • Flavivirus
  • Inactivated
  • Japanese encephalitis
  • Live attenuated
  • Vaccine

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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