Current use and development of vaccines for Japanese encephalitis

David Beasley, Penny Lewthwaite, Tom Solomon

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Background: Japanese encephalitis (JE) is a significant cause of human morbidity and mortality throughout Asia. Vaccines for JE have been available for many years and their use has been effective in reducing the incidence of A disease in several countries but, as disease incidence has decreased, concerns regarding adverse events following immunisation have increased. Objective: To review existing JE vaccines and new candidates in advanced preclinical or clinical evaluation. Methods: The review primarily covers published and some unpublished literature from the past decade describing current use of approved A vaccines in various parts of the world, and advanced development and clinical testing of alternative vaccine candidates. Results/conclusion: There is a clear need for additional licensing of existing or new A vaccines. Several promising candidates are currently in use or completing clinical trials.

Original languageEnglish (US)
Pages (from-to)95-106
Number of pages12
JournalExpert Opinion on Biological Therapy
Volume8
Issue number1
DOIs
StatePublished - Jan 2008

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Japanese Encephalitis Vaccines
Vaccines
Japanese Encephalitis
Immunization
Incidence
Licensure
Clinical Trials
Morbidity
Mortality
Testing

Keywords

  • Chimeric
  • Flavivirus
  • Inactivated
  • Japanese encephalitis
  • Live attenuated
  • Vaccine

ASJC Scopus subject areas

  • Pharmacology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics
  • Immunology

Cite this

Current use and development of vaccines for Japanese encephalitis. / Beasley, David; Lewthwaite, Penny; Solomon, Tom.

In: Expert Opinion on Biological Therapy, Vol. 8, No. 1, 01.2008, p. 95-106.

Research output: Contribution to journalArticle

Beasley, David ; Lewthwaite, Penny ; Solomon, Tom. / Current use and development of vaccines for Japanese encephalitis. In: Expert Opinion on Biological Therapy. 2008 ; Vol. 8, No. 1. pp. 95-106.
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