CXCL12-CXCR4 在人类恶性肿瘤中的生物学功能

Translated title of the contribution: Biological Functions of CXCL12-CXCR4 in Human Malignant Tumors

Sen Wang, Ji Xian Luo, Istvan Boldogh

    Research output: Contribution to journalReview articlepeer-review


    Metastasis and cell infiltration are the difficulties in the treatment of solid and lymphatic carcinoma and the main causes of disease recurrence and death. The migration of cancer cells is a prerequisite for tumor metastasis and invasion. The CXCL12-CXCR4 pathway plays an important role in the pathogenesis of solid tumors and leukemia. The interaction between CXCL12 and its receptor CXCR4 can activate multiple signaling pathways and regulate different physiological and pathophysiological processes. Thus, blocking CXCL12-CXCR4 binding and / or downstream pathways has clinical benefits in treating a variety of diseases and cancers. Although some CXCL12 and CXCR4 antagonists have been identified and have shown encouraging results in terms of antitumor activity, these drugs have not been widely used in clinical patients due to their serious toxic and side effects. There is an urgent need to develop novel CXCL12-CXCR4 axis antagonists for the treatment of tumors. Herein, we review the recent research progress of CXCR4 pathway in solid tumors and leukemia, and discuss the therapeutic value and future research direction of CXCR4 pathways in solid tumors and leukemia.

    Translated title of the contributionBiological Functions of CXCL12-CXCR4 in Human Malignant Tumors
    Original languageChinese (Traditional)
    Pages (from-to)577-586
    Number of pages10
    JournalChinese Journal of Biochemistry and Molecular Biology
    Issue number5
    StatePublished - May 20 2022


    • C-X-C chemokine receptor 4 (CXCR4)
    • C-X-C motif ligand 12 (CXCL12)
    • cancer
    • leukemia
    • pathways

    ASJC Scopus subject areas

    • Biochemistry
    • Biotechnology
    • Molecular Biology
    • Cancer Research


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