TY - JOUR
T1 - Cyanotic congenital heart disease following fertility treatments in the United States from 2011 to 2014
AU - Shamshirsaz, Alireza A.
AU - Bateni, Zhoobin H.
AU - Sangi-Haghpeykar, Haleh
AU - Arian, Sara E.
AU - Erfani, Hadi
AU - Shamshirsaz, Amir A.
AU - Abuhamad, Alfred
AU - Fox, Karin A.
AU - Ramin, Susan M.
AU - Moaddab, Amirhossein
AU - Maskatia, Shiraz A.
AU - Salmanian, Bahram
AU - Lopez, Keila N.
AU - Hosseinzadeh, Pardis
AU - Schutt, Amy K.
AU - Nassr, Ahmed A.
AU - Espinoza, Jimmy
AU - Dildy, Gary A.
AU - Belfort, Michael A.
AU - Clark, Steven L.
N1 - Publisher Copyright:
© 2018 Article author(s). All rights reserved.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Objective: To examine the risk for cyanotic congenital heart diseases (CCHDs) among live births in the USA, resulting from various forms of infertility treatments. Methods: This study is a cross-sectional analysis of live births in the USA from 2011 to 2014. Infertility treatments are categorised into two of the following groups on birth certificates: assisted reproductive technology (ART) fertility treatment (surgical egg removal; eg, in vitro fertilisation and gamete intrafallopian transfer) and non-ART fertility treatment (eg, medical treatment and intrauterine insemination). We compared the risk for CCHD in ART and non-ART fertility treatment groups with those infants whose mothers received no documented fertility treatment and were naturally conceived (NC). Results: Among 14 242 267 live births from 2011 to 2014, a total of 101 494 live births were in the ART and 81 242 resulted from non-ART fertility treatments. CCHD prevalence in ART, non-ART and NC groups were 393/100 892 (0.39%), 210/80 884 (0.26%) and 10 749/14 020 749 (0.08%), respectively. As compared with naturally conceiving infants, risk for CCHD was significantly higher among infants born in ART (adjusted relative risk (aRR) 2.4, 95% CI 2.1 to 2.7) and non-ART fertility treatment groups (aRR 1.9, 95% CI 1.6 to 2.2). Absolute risk increase in CCHD due to ART and non-ART treatments were 0.03% and 0.02%, respectively. A similar pattern was observed when the analysis was restricted to twins, newborns with birth weights under 1500 g and gestational age of less than 32 weeks. Conclusions: Our findings suggest an increased risk for CCHD in infants conceived after all types of infertility treatment.
AB - Objective: To examine the risk for cyanotic congenital heart diseases (CCHDs) among live births in the USA, resulting from various forms of infertility treatments. Methods: This study is a cross-sectional analysis of live births in the USA from 2011 to 2014. Infertility treatments are categorised into two of the following groups on birth certificates: assisted reproductive technology (ART) fertility treatment (surgical egg removal; eg, in vitro fertilisation and gamete intrafallopian transfer) and non-ART fertility treatment (eg, medical treatment and intrauterine insemination). We compared the risk for CCHD in ART and non-ART fertility treatment groups with those infants whose mothers received no documented fertility treatment and were naturally conceived (NC). Results: Among 14 242 267 live births from 2011 to 2014, a total of 101 494 live births were in the ART and 81 242 resulted from non-ART fertility treatments. CCHD prevalence in ART, non-ART and NC groups were 393/100 892 (0.39%), 210/80 884 (0.26%) and 10 749/14 020 749 (0.08%), respectively. As compared with naturally conceiving infants, risk for CCHD was significantly higher among infants born in ART (adjusted relative risk (aRR) 2.4, 95% CI 2.1 to 2.7) and non-ART fertility treatment groups (aRR 1.9, 95% CI 1.6 to 2.2). Absolute risk increase in CCHD due to ART and non-ART treatments were 0.03% and 0.02%, respectively. A similar pattern was observed when the analysis was restricted to twins, newborns with birth weights under 1500 g and gestational age of less than 32 weeks. Conclusions: Our findings suggest an increased risk for CCHD in infants conceived after all types of infertility treatment.
KW - congenital heart disease
KW - echocardiography
KW - epidemiology
UR - https://www.scopus.com/pages/publications/85047272618
UR - https://www.scopus.com/pages/publications/85047272618#tab=citedBy
U2 - 10.1136/heartjnl-2017-312015
DO - 10.1136/heartjnl-2017-312015
M3 - Article
C2 - 29146625
AN - SCOPUS:85047272618
SN - 1355-6037
VL - 104
SP - 945
EP - 948
JO - Heart
JF - Heart
IS - 11
ER -