Cyclic adenosine monophosphate response to prostaglandin E2 on subpopulations of human lymphocytes

James Goodwin, P. A. Kaszubowski, R. C. Williams

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Receptors for prostaglandin E2 or histamine were measured on subpopulations of human lymphocytes, using the cyclic AMP increase after exposure to prostaglandin or histamine as an indicator for the presence of receptors. The cyclic AMP response to prostaglandin E2 was similar in unfractionated lymphocytes and the T-enriched and T-depleted fractions. Within the T-enriched population, T cells bearing a receptor for the Fc portion of IgG (Tγ cells) had a 27.4-fold rise in cyclic AMP after exposure to prostaglandin E2, whereas the remaining T cells (non-Tγ cells) had a fourfold increase. It would appear that prostaglandin receptors are concentrated on a small subfraction of Tγ cells, comprising ~15% of the T-cell population. The cyclic AMP response to histamine was less than twofold in all lymphocyte fractions.

Original languageEnglish (US)
Pages (from-to)1260-1264
Number of pages5
JournalJournal of Experimental Medicine
Volume150
Issue number5
StatePublished - 1979
Externally publishedYes

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Lymphocyte Subsets
Dinoprostone
Cyclic AMP
T-Lymphocytes
Histamine
Lymphocytes
Prostaglandin Receptors
Histamine Receptors
Fc Receptors
Population
Prostaglandins
Immunoglobulin G

ASJC Scopus subject areas

  • Immunology

Cite this

Cyclic adenosine monophosphate response to prostaglandin E2 on subpopulations of human lymphocytes. / Goodwin, James; Kaszubowski, P. A.; Williams, R. C.

In: Journal of Experimental Medicine, Vol. 150, No. 5, 1979, p. 1260-1264.

Research output: Contribution to journalArticle

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