Cyst(e)ine measurements during total parenteral nutrition

M. H. Malloy; D. K. Rassin; C. J. Richardson

doi:10.1093/ajcn/37.2.188

Cyst(e)ine measurements during total parenteral nutrition

M. H. Malloy, D. K. Rassin, C. J. Richardson

Pediatrics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Using a method that measures plasma protein-bound 1/2 cystine, plasma free cyst(e)ine, and urine free cyst(e)ine, we have observed that infants receiving total parenteral nutrition supplemented with cysteine-HCl have significantly higher plasma and urine free cyst(e)ine concentrations (11.3 ± 3.4 μm/dl and 47.2 ± 24.0 μm/dl x̄ ± SD) than when 1/2 cystine concentrations are measured by automated amino acid analysis (7.4 ± 2.0 μm/dl, plasma and 25.0 ± 7.0 μm/dl, urine). These data suggest that both the sulfhydryl and disulfide form of cyst(e)ine must be measured to assess the effect of cysteine-HCl supplemented total parenteral nutrition.

Original language	English (US)
Pages (from-to)	188-191
Number of pages	4
Journal	American Journal of Clinical Nutrition
Volume	37
Issue number	2
DOIs	https://doi.org/10.1093/ajcn/37.2.188
State	Published - 1983

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

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abstract = "Using a method that measures plasma protein-bound 1/2 cystine, plasma free cyst(e)ine, and urine free cyst(e)ine, we have observed that infants receiving total parenteral nutrition supplemented with cysteine-HCl have significantly higher plasma and urine free cyst(e)ine concentrations (11.3 ± 3.4 μm/dl and 47.2 ± 24.0 μm/dl {\=x} ± SD) than when 1/2 cystine concentrations are measured by automated amino acid analysis (7.4 ± 2.0 μm/dl, plasma and 25.0 ± 7.0 μm/dl, urine). These data suggest that both the sulfhydryl and disulfide form of cyst(e)ine must be measured to assess the effect of cysteine-HCl supplemented total parenteral nutrition.",

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AU - Malloy, M. H.

AU - Rassin, D. K.

AU - Richardson, C. J.

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N2 - Using a method that measures plasma protein-bound 1/2 cystine, plasma free cyst(e)ine, and urine free cyst(e)ine, we have observed that infants receiving total parenteral nutrition supplemented with cysteine-HCl have significantly higher plasma and urine free cyst(e)ine concentrations (11.3 ± 3.4 μm/dl and 47.2 ± 24.0 μm/dl x̄ ± SD) than when 1/2 cystine concentrations are measured by automated amino acid analysis (7.4 ± 2.0 μm/dl, plasma and 25.0 ± 7.0 μm/dl, urine). These data suggest that both the sulfhydryl and disulfide form of cyst(e)ine must be measured to assess the effect of cysteine-HCl supplemented total parenteral nutrition.

AB - Using a method that measures plasma protein-bound 1/2 cystine, plasma free cyst(e)ine, and urine free cyst(e)ine, we have observed that infants receiving total parenteral nutrition supplemented with cysteine-HCl have significantly higher plasma and urine free cyst(e)ine concentrations (11.3 ± 3.4 μm/dl and 47.2 ± 24.0 μm/dl x̄ ± SD) than when 1/2 cystine concentrations are measured by automated amino acid analysis (7.4 ± 2.0 μm/dl, plasma and 25.0 ± 7.0 μm/dl, urine). These data suggest that both the sulfhydryl and disulfide form of cyst(e)ine must be measured to assess the effect of cysteine-HCl supplemented total parenteral nutrition.

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Cyst(e)ine measurements during total parenteral nutrition

Abstract

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