Cysteine sulfinic acid decarboxylase activity is not affected when measured in vitro in the presence of pyridoxal phosphate in the brains of vitamin B6-deficient rats. Activity of this enzyme was not detectable in the brains of vitamin B6-deficient animals when assayed in the absence of pyridoxal phosphate. The activity of cysteine sulfinic acid decarboxylase in crude particulate and soluble fractions of rat brain reflects the distribution of the enzyme in vivo and the distribution of endogenous B6 vitamers when assayed in the presence and absence of vitamin B6. This study indicates that virtually no taurine is synthesized by any component of brain when the animal is subjected to a deficiency of vitamin B6.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)