Cystic fibrosis: Characterization of the inhibitor to ciliary action in oyster gills

Barbara H. Bowman, Michael L. McCombs, Lillian Lockhart

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The inhibitor to oyster ciliary activity was isolated from serum of cystic fibrosis patients and heterozygotes. The inhibiting protein fraction was a cation as judged by electrophoresis; it had a molecular weight of 125,000 to 200,000 as judged by gel filtration; and on diethylaminoethyl-cellulose chromatography it eluted with the immunoglobulin G fraction. The analogous fraction in normal individuals did not inhibit oyster ciliary activity.

Original languageEnglish (US)
Pages (from-to)871-873
Number of pages3
JournalScience
Volume167
Issue number3919
StatePublished - 1970

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Ostreidae
Cystic Fibrosis
Heterozygote
Cellulose
Gel Chromatography
Electrophoresis
Cations
Chromatography
Immunoglobulin G
Molecular Weight
Serum
Proteins

ASJC Scopus subject areas

  • General

Cite this

Cystic fibrosis : Characterization of the inhibitor to ciliary action in oyster gills. / Bowman, Barbara H.; McCombs, Michael L.; Lockhart, Lillian.

In: Science, Vol. 167, No. 3919, 1970, p. 871-873.

Research output: Contribution to journalArticle

Bowman, Barbara H. ; McCombs, Michael L. ; Lockhart, Lillian. / Cystic fibrosis : Characterization of the inhibitor to ciliary action in oyster gills. In: Science. 1970 ; Vol. 167, No. 3919. pp. 871-873.
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