Cystic fibrosis: The ciliary inhibitor is a small polypeptide associated with immunoglobulin G

B. H. Bowman, B. J. Lankford, G. M. Fuller, S. D. Carson, A. Kurosky, D. R. Barnett

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    A small polypeptide within the molecular weight range of 6,000 to 11,000 was found in immunoglobulin fractions from sera of cystic fibrosis homozygotes and heterozygotes. This factor appears to be responsible for interfering with ciliary activity in oyster gills. Since it can be dissociated from IgG without reductive cleavage it must be bound in a non-covalent manner. After its dissociation the IgG fractions from cystic fibrosis sera no longer inhibited ciliary activity. This finding explains the differences previously observed in the molecular weights of the ciliary inhibitor synthesized by cultured cells and that of sera from cystic fibrosis genotypes.

    Original languageEnglish (US)
    Pages (from-to)1310-1315
    Number of pages6
    JournalBiochemical and Biophysical Research Communications
    Volume64
    Issue number4
    DOIs
    StatePublished - Jun 16 1975

    Fingerprint

    Cystic Fibrosis
    Immunoglobulin G
    Molecular weight
    Peptides
    Molecular Weight
    Serum
    Immunoglobulins
    Ostreidae
    Cells
    Homozygote
    Heterozygote
    Cultured Cells
    Genotype
    ciliary dyskinesia factor

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

    Cite this

    Cystic fibrosis : The ciliary inhibitor is a small polypeptide associated with immunoglobulin G. / Bowman, B. H.; Lankford, B. J.; Fuller, G. M.; Carson, S. D.; Kurosky, A.; Barnett, D. R.

    In: Biochemical and Biophysical Research Communications, Vol. 64, No. 4, 16.06.1975, p. 1310-1315.

    Research output: Contribution to journalArticle

    Bowman, B. H. ; Lankford, B. J. ; Fuller, G. M. ; Carson, S. D. ; Kurosky, A. ; Barnett, D. R. / Cystic fibrosis : The ciliary inhibitor is a small polypeptide associated with immunoglobulin G. In: Biochemical and Biophysical Research Communications. 1975 ; Vol. 64, No. 4. pp. 1310-1315.
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