Cytogenetic analysis of a primary salivary gland myoepithelioma

Adel K. El-Naggar, Mercedes Lovell, David L. Callender, Nelson G. Ordonez, Ann M. Killary

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    29 Scopus citations

    Abstract

    Myoepithelioma, a rare benign salivary gland neoplasm, is a tumor composed entirely of myoepithelial cells. Unlike pleomorphic adenoma, these tumors lack any ductal epithelial differentiation, and manifest a minor stromal element. Previous cytogenetic and molecular genetic studies have mainly investigated pleomorphic adenomas and reported recurring specific chromosomal alterations at 8q12 and 12q13~q15 regions. The cell origin of these alterations, however, remains speculative. We report the cytogenetic analysis of a parotid myoepithelioma and discuss the putative origin for the cells with cytogenetic alterations. Our analysis shows 12q12 involved in a translocation with a previously unreported partner (1q), and nonrandom del(9)(q22.1q22.3) and del(13)(q12q22). Our results indicate that the myoepithelial cell is the source of those cells with chromosomal alterations, and that myoepithelioma shares 12q alterations reported in a subset of pleomorphic adenomas. Copyright (C) 1999 Elsevier Science Inc.

    Original languageEnglish (US)
    Pages (from-to)49-53
    Number of pages5
    JournalCancer Genetics and Cytogenetics
    Volume113
    Issue number1
    DOIs
    StatePublished - Aug 1 1999

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    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics
    • Cancer Research

    Cite this

    El-Naggar, A. K., Lovell, M., Callender, D. L., Ordonez, N. G., & Killary, A. M. (1999). Cytogenetic analysis of a primary salivary gland myoepithelioma. Cancer Genetics and Cytogenetics, 113(1), 49-53. https://doi.org/10.1016/S0165-4608(98)00280-5