Cytogenetic analysis of a primary salivary gland myoepithelioma

Adel K. El-Naggar, Mercedes Lovell, David L. Callender, Nelson G. Ordonez, Ann M. Killary

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Myoepithelioma, a rare benign salivary gland neoplasm, is a tumor composed entirely of myoepithelial cells. Unlike pleomorphic adenoma, these tumors lack any ductal epithelial differentiation, and manifest a minor stromal element. Previous cytogenetic and molecular genetic studies have mainly investigated pleomorphic adenomas and reported recurring specific chromosomal alterations at 8q12 and 12q13~q15 regions. The cell origin of these alterations, however, remains speculative. We report the cytogenetic analysis of a parotid myoepithelioma and discuss the putative origin for the cells with cytogenetic alterations. Our analysis shows 12q12 involved in a translocation with a previously unreported partner (1q), and nonrandom del(9)(q22.1q22.3) and del(13)(q12q22). Our results indicate that the myoepithelial cell is the source of those cells with chromosomal alterations, and that myoepithelioma shares 12q alterations reported in a subset of pleomorphic adenomas. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)49-53
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume113
Issue number1
DOIs
StatePublished - Aug 1 1999

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    El-Naggar, A. K., Lovell, M., Callender, D. L., Ordonez, N. G., & Killary, A. M. (1999). Cytogenetic analysis of a primary salivary gland myoepithelioma. Cancer Genetics and Cytogenetics, 113(1), 49-53. https://doi.org/10.1016/S0165-4608(98)00280-5